3-Aminopyridazine hydrochloride

Table of Contents

• 1. Product Overview
• 2. Specifications & Comparative Analysis
• 3. Key Applications
• 4. Industrial Case Studies
• 5. Usage Guidelines
• 6. Contact for Custom Solutions

1. Product Overview

3-Aminopyridazine Hydrochloride: Core Characteristics

A high-purity heterocyclic compound (CAS 6294-28-8) with molecular formula C₄H₆ClN₃, extensively used as:

• Pharmaceutical intermediate for kinase inhibitors
• Ligand in metal-organic frameworks (MOFs)
• Precursor for agrochemical active ingredients

2. Specifications & Comparative Analysis

3. Key Applications

3.1 Drug Discovery Applications

Critical intermediate in developing:

• JAK/STAT pathway inhibitors (Phase II oncology candidates)
• Antiviral prodrugs with >80% bioavailability
• Neuroprotective agents targeting NMDA receptors

3.2 Advanced Material Synthesis

Used in creating:

• Photoactive coordination polymers (λ_max 320 nm)
• Conductive thin films for flexible electronics

4. Industrial Case Studies

Case Study 1: Oncology API Development

Client: Top 10 Global Pharma Company

Challenge: Scalable synthesis of BTK inhibitor intermediate

Solution: Optimized Pd-catalyzed amination using 3-Aminopyridazine HCl

Outcome: 92% yield at 500 kg scale, reduced metal residues <0.5 ppm

Case Study 2: Agrochemical Formulation

Client: EU-based Crop Science Leader

Challenge: Develop systemic fungicide with rainfastness >72hr

Solution: Pyridazine-derived active metabolite synthesis

Result: Field efficacy increased 40% vs. commercial benchmarks

5. Usage Guidelines

5.1 Handling Protocols

• PPE Requirement: Nitrile gloves, Type IIR mask
• Reaction Conditions: Stable below 150°C (ΔH_dec = 210 kJ/mol)

5.2 Storage Recommendations

• Desiccated storage (RH <10%)
• Nitrogen atmosphere for >5 year stability

6. Contact for Custom Solutions

Request technical packages including:

• cGMP-compliant synthesis routes
• Regulatory support packages (REACH, DMF)
• Custom particle size distributions (10-200 µm)

Contact our technical team:
Email: info@vivalr.com
Tel: (86) 15866781826