Comprehensive Guide to 2-Chloro-3-fluoropyridine
Table of Contents
- 1. Product Overview
- 2. Key Specifications & Comparative Analysis
- 3. Industrial Applications
- 4. Application Case Studies
- 5. Client Success Stories
- 6. Request Customized Solutions
1. Product Overview
2-Chloro-3-fluoropyridine (CAS 1480-65-5) is a halogenated pyridine derivative with molecular formula C5H3ClFN. This heterocyclic compound features:
- Molecular Weight: 131.53 g/mol
- Appearance: Colorless to pale yellow liquid
- Boiling Point: 142-144°C at 760 mmHg
- Density: 1.398 g/cm3 at 25°C
2. Key Specifications & Comparative Analysis
| Parameter | 2-Chloro-3-fluoropyridine | 2-Chloropyridine | 3-Fluoropyridine |
|---|---|---|---|
| Reactivity Index | 0.78 | 0.65 | 0.71 |
| Pharmaceutical Compatibility | High | Medium | Low |
| Thermal Stability | Up to 200°C | 180°C | 190°C |
3. Industrial Applications
3.1 Pharmaceutical Intermediate
Used in synthesizing:
- Kinase inhibitors (e.g., EGFR inhibitors)
- Antiviral agents
- Neuropharmaceuticals
3.2 Agrochemical Production
Key component in:
- Next-gen herbicides (e.g., Fluroxypyr derivatives)
- Insect growth regulators
4. Application Case Studies
4.1 Anticancer Drug Development
Used as core structure in third-generation BTK inhibitors showing 89% improved bioavailability compared to previous analogs.
4.2 Electronic Materials
Implemented in OLED electron transport layers, achieving 15% efficiency improvement in prototype displays.
5. Client Success Stories
5.1 European Pharma Leader
“Vivalr’s 2-Chloro-3-fluoropyridine enabled 40% faster synthesis of our lead oncology candidate while maintaining 99.8% purity throughout scale-up.”
5.2 US Agrochemical Innovator
“The compound’s unique reactivity profile helped us develop a breakthrough herbicide with 92% weed control efficacy at half the application rate.”
6. Request Customized Solutions
Our capabilities include:
- Bulk quantities (100kg+ batches)
- Custom purity grades (98%-99.9%)
- Stable isotope-labeled versions
Contact our technical team:
Email: info@vivalr.com
Tel: (86) 15866781826


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