4-Amino-6-Mercaptopyrazolo[3,4-d]Pyrimidine: Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
Chemical Profile
IUPAC Name: 4-Amino-6-mercaptopyrazolo[3,4-d]pyrimidine
CAS Number: 6854-49-5
Molecular Formula: C5H5N5S
Molecular Weight: 167.2 g/mol
Appearance: Off-white to pale yellow crystalline powder
Comparative Analysis
| Parameter | 4-Amino-6-MP | 6-Mercaptopurine (6-MP) | Thioguanine |
|---|---|---|---|
| Solubility (Water) | ≥5 mg/mL | 1.2 mg/mL | 0.6 mg/mL |
| Purity (HPLC) | ≥98% | 95-97% | 97% |
| Stability | 24 months at -20°C | 18 months | 12 months |
2. Key Applications & Use Cases
Pharmaceutical Development
- Kinase Inhibitors: Acts as core scaffold in JAK2/STAT3 pathway inhibitors
- Anticancer Agents: Demonstrated IC50 values ≤50 nM in leukemia cell lines
- Antiviral Research: Targets viral RNA polymerase in preclinical studies
Biochemical Research
- Used in nucleotide analog studies with 89% binding efficiency
- Critical component in enzyme inhibition assays (Ki = 2.3 μM)
3. Industry Applications
Recommended Protocols
| Application | Concentration | Incubation Time |
|---|---|---|
| Cell Culture Studies | 10-100 μM | 24-72 hours |
| In Vivo Models | 5 mg/kg/day | 14-day cycles |
4. Customer Case Studies
Case Study 1: Oncology Therapeutics Development
Client: EuroPharma Solutions (Frankfurt, Germany)
Challenge: Required high-purity kinase inhibitor precursor for AML research
Solution: Custom synthesis with 99.2% purity via HPLC
Result: 63% reduction in blast cell proliferation at 40 μM concentration
Case Study 2: Antiviral Research
Client: BioViral Technologies (San Diego, USA)
Application: RNA virus polymerase inhibition screening
Outcome: Achieved 82% viral load reduction at 25 μM dose
5. Technical Support & Inquiries
For batch-specific COA, custom synthesis requests, or technical documentation:
| Contact Method | Details |
|---|---|
| info@vivalr.com | |
| Phone | (86) 15866781826 (24/7 Support) |
Lead Time: Standard samples ship within 3-5 business days


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