5-Bromo-2-fluoro-4-methyl-pyridine

5-Bromo-2-fluoro-4-methyl-pyridine: Ultimate Buyer’s Guide & Application Insights

Table of Contents

• Product Overview & Key Specifications
• Industrial Applications & Functional Advantages
• Operational Guidelines & Safety Protocols
• Synthesis Case Studies in Pharma/Chemistry
• Verified Client Success Stories
• Custom Synthesis Inquiry & Technical Support

1. Product Overview & Key Specifications

CAS No: 374633-71-3
Molecular Formula: C6H5BrFN
Molecular Weight: 190.01 g/mol
Appearance: White to off-white crystalline powder
Purity (HPLC): ≥98% (Standard Grade), ≥99.5% (Research Grade)

2. Industrial Applications & Functional Advantages

Primary applications in:

• Pharmaceutical Intermediates: Key building block for kinase inhibitors (EGFR, ALK)
• Agrochemical Synthesis: Precursor for next-gen fungicides/pesticides
• Material Science: Ligand in transition metal catalysis systems

Structural advantages enable:

• Enhanced reactivity in Suzuki-Miyaura cross-coupling
• Directed regioselectivity in SNAr reactions
• Improved metabolic stability in drug candidates

3. Operational Guidelines & Safety Protocols

Storage: 2-8°C in inert atmosphere (Ar/N₂)
Handling: Use NIOSH-approved respirator & neoprene gloves
Reactivity: Avoid strong oxidizers & metallic sodium
First Aid: Flush eyes with water for 15 mins if contacted

4. Synthesis Case Studies in Pharma/Chemistry

Case 1: Lorlatinib Intermediate Synthesis
– Reaction: Buchwald-Hartwig amination (Pd2(dba)3/XPhos)
– Yield Improvement: 68% → 82% via optimized bromine activation

Case 2: Isoflucypram Fungicide Development
– Key Step: Nucleophilic aromatic substitution with thiols
– Process Scale: 200kg batch with 99.2% conversion rate

5. Verified Client Success Stories

Client 1: Top 10 Pharma Company (EU)
– Application: Third-generation ALK inhibitor R&D
– Volume: 35kg/month under cGMP
– Outcome: Reduced genotoxic impurities by 90% vs previous supplier

Client 2: Agrochemical Leader (USA)
– Project: Broad-spectrum fungicide formulation
– Technical Support: Co-developed custom purification protocol
– Result: Achieved 24-month shelf stability under ICH Q1A

6. Custom Synthesis Inquiry & Technical Support

Request tailored solutions:
– Custom purity (Up to 99.95%)
– Isotope-labeled versions (13C/15N)
– Kilo-lab to production-scale synthesis

Contact our technical team:
✉️ info@vivalr.com
(86) 15866781826