4-Bromopyridine Hydrochloride: Comprehensive User Guide
Table of Contents
- 1. Product Overview & Specifications
- 2. Applications & Industrial Uses
- 3. Usage Guidelines & Best Practices
- 4. Case Studies & Real-World Examples
- 5. Client Success Stories
- 6. Request Customized Solutions
1. Product Overview & Specifications
| Parameter | 4-Bromopyridine HCl | Comparable Compound (4-Chloropyridine HCl) |
|---|---|---|
| CAS Number | 20039-91-0 | 1452-89-9 |
| Molecular Formula | C5H5BrN·HCl | C5H5ClN·HCl |
| Purity | ≥98% (HPLC) | ≥97% |
| Reactivity | Superior in Suzuki couplings | Lower cross-coupling efficiency |
2. Applications & Industrial Uses
Pharmaceutical Intermediates
Critical for synthesizing kinase inhibitors in oncology research, particularly in EGFR-targeted therapies.
Agrochemical Development
Used in creating novel neonicotinoid derivatives with improved insecticidal activity and reduced environmental persistence.
3. Usage Guidelines & Best Practices
Reaction Optimization
Recommended conditions for Buchwald-Hartwig amination:
| Parameter | Optimal Range |
|---|---|
| Temperature | 80-100°C |
| Catalyst | Pd(dppf)Cl2 |
4. Case Studies
Antiviral Drug Synthesis
Key intermediate in remdesivir analog production:
| Step | Yield Improvement |
|---|---|
| Bromination | 82% → 89% |
5. Client Success Stories
Shanghai PharmaTech Co., Ltd.
Application: PARP inhibitor development
Result: Reduced synthesis steps from 7 to 4
Feedback: “Enhanced reaction selectivity accelerated our preclinical timeline”
6. Request Customized Solutions
Contact our technical team for batch-specific certificates or formulation advice:
Email: info@vivalr.com
Tel: (86) 15866781826
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