Parameter | Specification | 2-Pyridineacetic Acid | Pyridylacetic Acid Derivatives |
---|---|---|---|
Chemical Formula | C7H8ClNO2 | C7H7NO2 | Variable |
Molecular Weight | 189.60 g/mol | 137.14 g/mol | 150-250 g/mol |
Purity Grade | ≥98% (HPLC) | ≥95% | 90-99% |
Storage Temperature | 2-8°C | Room Temperature | Variable |
Pharmaceutical Intermediate: Critical component in synthesizing antihypertensive agents and CNS-targeted therapeutics.
Organic Synthesis: Building block for chiral ligands in asymmetric catalysis (e.g., enantioselective hydrogenation).
Coordination Chemistry: Chelating agent for transition metal complexes in catalytic systems.
Handling Protocols:
Case 1: Anticonvulsant Drug Synthesis
Reaction: Nucleophilic substitution with 4-fluorobenzyl bromide
Yield Improvement: 72% → 88% through optimized stoichiometry
Case 2: Ruthenium Complex Preparation
Application: Hydrogenation catalyst for ketone reduction
TOF Achieved: 1,200 h⁻¹ (superior to commercial alternatives)
Client 1: PharmaSynth Inc. (USA)
Application: PDE5 inhibitor intermediate production
Results: 40% cost reduction vs. traditional synthesis routes
Client 2: ChemResearch Labs (Germany)
Application: Chiral ligand for enantioselective alkylation
Outcome: 92% ee achieved in β-lactam formation
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