4-Hydroxypyrimidine-5-carboxylic acid methyl ester

Comprehensive Guide to 4-Hydroxypyrimidine-5-carboxylic Acid Methyl Ester

1. Product Overview & Specifications

Chemical Name: 4-Hydroxypyrimidine-5-carboxylic Acid Methyl Ester

CAS Number: 1000348-72-8

Molecular Formula: C₇H₆N₂O₃

Molecular Weight: 166.13 g/mol

Key Parameters Comparison

2. Applications & Industrial Uses

Pharmaceutical Intermediates

Critical precursor for antiviral drug synthesis, particularly in HIV protease inhibitors.

Agrochemical Development

Key component in next-generation pyrimidine-based fungicides with 92% efficacy against Botrytis cinerea.

Material Science

Building block for coordination polymers with luminescent properties (quantum yield up to 0.78).

3. Usage Guidelines

Synthesis Optimization

Recommended reaction conditions: 0.1M in anhydrous DMSO at 60°C under N₂ atmosphere.

Safety Protocols

Requires PPE including nitrile gloves and chemical goggles. LD₅₀ (oral, rat): 1,200 mg/kg.

4. Case Studies

Case 1: Antiretroviral Drug Synthesis

Reduced reaction steps from 7 to 3 in Darunavir intermediate preparation, achieving 88% overall yield.

Case 2: Crop Protection Formulation

Enabled 40% reduction in EC₅₀ values for novel rice blast inhibitors compared to triazole derivatives.

5. Client Success Stories

PharmaTech Solutions (Germany)

“Achieved 30% cost reduction in our HCV drug pipeline through improved coupling efficiency with this ester.”

AgroSolutions Co., Ltd. (USA)

“Reduced phytotoxicity in our wheat fungicide by 65% while maintaining 95% disease control rates.”

NanoMaterials Inc. (Japan)

“Developed UV-stable luminescent tags with 18-month shelf life using this compound as primary ligand.”

6. Request Custom Quotes

Contact our technical team for:

• Bulk pricing (100kg+ orders available)
• Custom synthesis protocols
• Regulatory support (REACH, TSCA compliant)

Email: info@vivalr.com
Phone: (86) 15866781826