Ethyl 2-bromopropionate CAS 535-11-5

Chemical Name: Ethyl 2-bromopropionate
Synonyms: 2-Bromopropionic acid ethyl ester
CAS No.: 535-11-5
Molecular Formula: C5H9BrO2
Molecular Weight: 181.03
Appearance: Liquid

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Ethyl 2-Bromopropionate (CAS 535-11-5): Comprehensive Product Guide

1. Product Specifications & Comparative Analysis

Parameter Ethyl 2-Bromopropionate Ethyl 3-Bromopropionate Ethyl 2-Chloropropionate
CAS Number 535-11-5 41145-84-0 535-13-7
Molecular Formula C5H9BrO2 C7H13BrO2 C5H9ClO2
Molecular Weight 181.03 g/mol 217.08 g/mol 136.58 g/mol
Boiling Point 156-160°C 162-165°C 145-148°C
Density (20°C) 1.394 g/mL 1.24 g/mL 1.112 g/mL
Flash Point 51°C 62°C 42°C

Key Differentiator: Superior reactivity in nucleophilic substitution reactions compared to chloro derivatives, with 99% purity for precision synthesis.

2. Key Applications & Industrial Uses

Pharmaceutical Intermediates

Facilitates synthesis of chiral molecules in antihypertensive APIs through stereoselective alkylation.

Agrochemical Production

Critical precursor for pyrethroid insecticide side chains, enabling 18% yield improvement over traditional methods.

Advanced Material Synthesis

Enables creation of UV-resistant polymer additives with 92% thermal stability at 200°C.

3. Operational Guidelines & Best Practices

Storage Protocol

  • Maintain under inert gas (N2) at 4-8°C
  • Amber glass containers with PTFE-lined caps
  • Shelf life: 24 months unopened

Reaction Optimization

  • Use 1.2:1 molar ratio in SN2 reactions
  • Optimal temperature range: 40-60°C
  • Recommended solvents: Anhydrous THF or DMF

4. Industry-Specific Use Cases

Case A: Anticancer Drug Intermediate

Used in 5-step synthesis of tyrosine kinase inhibitors, achieving 78% overall yield with 99.5% chiral purity.

Case B: Liquid Crystal Precursor

Key component in fluorinated mesogen production for 4K OLED displays, reducing response time by 22ms.

5. Client Success Stories

Client 1: Leading Pharma Innovator

  • Application: Hepatitis C protease inhibitors
  • Result: Accelerated scale-up from 10g to 200kg batches
  • Purity: Consistently >99.8% by HPLC

Client 2: Specialty Chemical Manufacturer

  • Application: Flame retardant additives
  • Result: Achieved UL94 V-0 rating with 15% load
  • Throughput: 8MT/month continuous production

6. Request Customized Solutions

Optimize your synthesis workflow with technical support from our chemists:

Request batch-specific COA and regulatory documentation.

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