Chemical Name: Dextran sulfate sodium
Synonyms: Dextran Sulfate Sodium Salt
CAS No.: 9011-18-1
Molecular Formula: (C6H7Na3O14S3)n
Appearance: White Powder
Dextran Sulfate Sodium (CAS 9011-18-1) is a sulfated polysaccharide widely used in biomedical research. With variable molecular weights (5-500 kDa), it serves as critical component in colitis induction, anticoagulant studies, and virology research.
| Parameter | Grade 5kDa | Grade 40kDa | Grade 500kDa |
|---|---|---|---|
| Molecular Weight | 5,000 Da | 40,000 Da | 500,000 Da |
| Purity | >95% | >98% | >97% |
| Solubility | Water: 50 mg/mL | Water: 100 mg/mL | Water: 20 mg/mL |
| Key Application | Cell separation | DSS colitis models | Virus precipitation |
2-5% DSS solution in drinking water induces ulcerative colitis in rodents within 7 days, widely adopted for IBD mechanism studies.
Competes with heparin for binding to antithrombin III, used in thrombosis studies at 0.1-1 mg/mL concentrations.
Enhances HIV infectivity in T-cell cultures at 10 μg/mL while inhibiting reverse transcriptase activity at higher concentrations (>100 μg/mL).
Step 1: Prepare 3% DSS solution in autoclaved water
Step 2: Administer to C57BL/6 mice ad libitum for 5-7 days
Result: Develops weight loss (>15%), bloody diarrhea, and colon shortening within 7 days
Used at 50 μg/mL concentration to enhance lentivirus transduction efficiency in HEK293 cells by 300% compared to PEI methods.
Challenge: Needed reproducible IBD model for drug screening
Solution: Used 40kDa DSS at 2.5% concentration
Outcome: Achieved 90% model consistency across 15 test batches
Challenge: Required HIV-1 concentration from cell culture media
Solution: Implemented 500kDa DSS precipitation protocol
Outcome: Increased viral yield by 40% vs ultracentrifugation
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