3-BroMo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid CAS 500011-86-9

Comprehensive Guide to 3-Bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic Acid (CAS 500011-86-9)

Table of Contents

• Product Specifications & Comparative Analysis
• Functional Applications
• Operational Case Studies
• Industry Client Implementations
• Technical Consultation

1. Product Specifications & Comparative Analysis

*Comparative data shown for ethyl 3-bromo-1H-pyrazole-5-carboxylate (CAS 1886994-07-5)

2. Functional Applications

Core Industrial Utilities

• Agrochemical Intermediate: Critical precursor for neonicotinoid insecticides
• Pharmaceutical Building Block: Key component in kinase inhibitor development
• Chemical Synthesis: Versatile substrate for cross-coupling reactions

Mechanistic Advantages

• Bromine atom enables efficient Buchwald-Hartwig amination
• Chloropyridinyl group enhances bioactivity in final products
• Acid functionality permits salt formation for improved solubility

3. Operational Case Studies

Case 1: Insecticide Development

Used in multi-step synthesis of clothianidin analogs through:
1. Suzuki-Miyaura coupling with boronic acids
2. Amidation with nitroguanidine derivatives
3. Final purification via recrystallization

Case 2: Pharmaceutical Research

Employed in cancer drug discovery for:
– Kinase binding motif construction
– Prodrug activation systems
– Targeted drug delivery conjugates

4. Industry Client Implementations

Client A: Agrochemical Manufacturer

• Application: Systemic insecticide production
• Scale: 500 kg/month continuous process
• Result: 22% yield improvement vs traditional intermediates

Client B: Contract Research Organization

• Application: Library synthesis for high-throughput screening
• Scale: 150 diverse analogs generated
• Result: 3 lead compounds identified for further development

5. Technical Consultation

Contact our experts for:
– Custom synthesis protocols
– Regulatory compliance guidance
– Bulk order specifications

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Technical Support Features

• MSDS documentation
• Stability data packages
• Process optimization consulting