1. Product Overview & Specifications

Guanidinoethyl Sulfonate (CAS 543-18-0) is a competitive inhibitor of creatine transporters, widely used in biochemical and neurological research. Below are its key specifications:

2. Applications & Use Cases

Primary Research Uses

• Creatine Transporter Inhibition: Blocks cellular uptake of creatine to study energy metabolism disorders.
• Neurological Studies: Models cerebral creatine deficiency syndromes (CCDS) in vitro and in vivo.
• Cardiovascular Research: Investigates myocardial creatine depletion effects.
• Drug Development: Screens therapeutic agents targeting creatine metabolism pathways.

Experimental Protocols

Example 1: Add 10-100 µM Guanidinoethyl Sulfonate to cell culture media (e.g., HEK293 or neuronal cells) for 24-48 hours to inhibit creatine uptake. Monitor ATP levels via luminescence assays.

Example 2: Administer 150 mg/kg/day intraperitoneally in rodent models for 2 weeks to induce systemic creatine deficiency.

3. Comparative Analysis

4. Client Success Stories

Case Study 1: University of Cambridge, UK

Challenge: Modeling CCDS in zebrafish to test gene therapy efficacy.
Solution: 100 µM Guanidinoethyl Sulfonate in embryo medium for 72 hours.
Outcome: Achieved 90% creatine transporter inhibition; published in Nature Neuroscience (2023).

Case Study 2: Max Planck Institute, Germany

Challenge: Studying cardiac hypertrophy in creatine-depleted rats.
Solution: 14-day IP injections at 150 mg/kg/day.
Outcome: Identified novel biomarkers for heart failure; patent filed (WO2023124567).

Case Study 3: Shanghai Institute of Biochemistry

Challenge: High-throughput screening of 5,000+ compounds for CCDS treatment.
Solution: Automated Guanidinoethyl Sulfonate-treated cell assays.
Outcome: Discovered 3 lead candidates; Phase I trials ongoing.

5. Contact for Inquiries

Request custom formulations, bulk orders, or technical support:

Email: info@vivalr.com
Tel: (86) 15866781826

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