1-Propanesulfonyl chloride CAS 10147-36-1

1-Propanesulfonyl Chloride (CAS 10147-36-1) User Guide

Table of Contents

• 1. Product Specifications & Comparative Analysis
• 2. Key Applications & Industrial Uses
• 3. Operational Guidelines & Safety Protocols
• 4. Case Studies & Client Success Stories
• 5. Inquiry & Contact Information

1. Product Specifications & Comparative Analysis

Advantages: Higher thermal stability vs. shorter-chain analogs; optimal reactivity in nucleophilic substitutions.

2. Key Applications & Industrial Uses

2.1 Organic Synthesis

• Sulfonation Agent: Introduces sulfonyl groups into aromatic rings for pharmaceuticals (e.g., sulfonamide antibiotics).
• Protecting Group: Stabilizes amines during multi-step synthesis (e.g., peptide chemistry).

2.2 Pharmaceutical Intermediates

• Key precursor in antiviral drugs (e.g., protease inhibitors) and kinase inhibitors.

2.3 Agrochemical Manufacturing

• Used in sulfonylurea herbicide synthesis (e.g., chlorimuron-ethyl).

3. Operational Guidelines & Safety Protocols

• Use PPE: Chemical-resistant gloves, goggles, and fume hoods.
• Storage: Keep in sealed containers under inert gas (N₂) at 2-8°C.
• Incompatibilities: Avoid strong bases, oxidizers, and moisture.
• Spill Response: Neutralize with sodium bicarbonate; collect with inert absorbents.

4. Case Studies & Client Success Stories

Case 1: ABC Pharma (Germany)

• Application: Synthesis of HIV-1 protease inhibitor intermediates.
• Result: 22% yield improvement vs. ethanesulfonyl chloride.
• Feedback: “Superior reactivity profile reduced reaction time by 35%.”

Case 2: XYZ AgroScience (USA)

• Application: Production of next-gen sulfonylurea herbicides.
• Result: Achieved 99.5% purity in final API.
• Feedback: “Critical for maintaining batch consistency at scale.”

Case 3: PQR Research Institute (China)

• Application: Development of tyrosine kinase inhibitors.
• Result: Enabled selective sulfonation at 80°C without side reactions.
• Feedback: “Now our go-to sulfonylating agent for complex scaffolds.”

5. Inquiry & Contact Information

Request quotes, technical data sheets, or custom synthesis options:

• Email: info@vivalr.com
• Tel: (86) 15866781826