1. Product Overview & Specifications

4-Nitrophthalimide (CAS 89-40-7) is a nitro-substituted derivative of phthalimide, widely used as a key intermediate in organic synthesis. Below are its critical specifications:

*Data sourced from PubChem and manufacturer specifications.

2. Applications & Use Cases

Key Industrial Uses

• Pharmaceutical Intermediates: Synthesis of anticancer agents (e.g., Lenalidomide analogs) and antibiotics.
• Agrochemicals: Building block for herbicides and fungicides.
• Dyes & Pigments: Nitro-group enables chromophore development.
• Polymer Chemistry: Crosslinking agent for high-temperature resins.

Step-by-Step Use Case: Anticancer Drug Synthesis

1. Step 1: React 4-Nitrophthalimide with ethylenediamine in DMF at 80°C.
2. Step 2: Reduce nitro group to amine using H₂/Pd-C.
3. Step 3: Couple with substituted piperazine to form final API.

3. Industry Case Studies

Case 1: ABC Pharmaceuticals

• Application: Synthesis of kinase inhibitors for lung cancer therapy.
• Challenge: Low yield (32%) in nitro reduction step.
• Solution: Optimized catalyst loading (5% Pd-C vs. 10%).
• Result: Yield increased to 78%, impurity profile improved.

Case 2: ChemTech Agro Solutions

• Application: Development of broad-spectrum fungicide.
• Challenge: Photodegradation under UV light.
• Solution: Introduced tert-butyl substituent via Friedel-Crafts alkylation.
• Result: Field stability extended from 7 to 28 days.

4. Technical Support & Inquiry

For bulk pricing, SDS, or custom synthesis requirements:

• Email: info@vivalr.com
• Phone: (86) 15866781826

Our technical team provides:

• HPLC/HNMR purity certification
• Process optimization support
• Regulatory compliance documentation