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Specialized inn-Tetradecyl-β-D-Maltoside CAS 18449-82-6and related product development and production

Chemical Name: n-Tetradecyl-β-D-Maltoside
CAS No.: 18449-82-6
Molecular Fomula: C26H50O11
Molecular weight: 538.67
Appearance: White powder
Assay: ≥99.0%

Samples: Available / Stock: Sufficient
Estimated delivery time: 3-5 days

n-Tetradecyl-β-D-Maltoside (CAS 18449-82-6): Comprehensive User Guide

Table of Contents

1. Product Overview & Specifications

n-Tetradecyl-β-D-Maltoside (CAS 18449-82-6) is a high-purity nonionic detergent widely used in membrane protein solubilization and stabilization. Key parameters:

Parameter Value
Molecular Weight 692.87 g/mol
Appearance White to off-white powder
Purity (HPLC) ≥98%
Critical Micelle Concentration (CMC) 0.0085% (w/v)
HLB Value 13.3

2. Key Applications & Use Cases

2.1 Membrane Protein Research

Enables gentle extraction of integral membrane proteins while maintaining structural integrity for:

  • X-ray crystallography studies
  • Cryo-EM sample preparation
  • Receptor-ligand binding assays

2.2 Biopharmaceutical Manufacturing

Critical for:

  • Vaccine antigen stabilization
  • Monoclonal antibody purification
  • Liposome formulation

3. Performance Comparison

Detergent CMC (%w/v) Protein Stability Cost Efficiency
n-Tetradecyl-β-D-Maltoside 0.0085 Excellent High
DDM (n-Dodecyl β-D-Maltoside) 0.009 Good Medium
Octyl Glucoside 0.6 Fair Low

4. Industry Case Studies

Case 1: Structural Biology Research

Client: ABC Biotech (Cambridge, UK)
Challenge: Poor GPCR stability in crystallization trials
Solution: 0.03% n-Tetradecyl-β-D-Maltoside in purification buffer
Result: 40% improvement in crystal resolution

Case 2: Vaccine Development

Client: XYZ Pharma (Boston, USA)
Challenge: Viral envelope protein aggregation
Solution: 0.01% detergent in formulation buffer
Result: Stable antigen preservation for 12 months at 4°C

5. Request Quote or Samples

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Drug impurities to intermediates. Years of expertise.

Experience in the synthesis of complex compounds derived from American technology
Focus on the synthesis of difficult compounds
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A 70+ R&D team led by Chinese and foreign doctors
150 pieces (sets) of R&D equipment, 120+ fume hoods
18 patents

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Through more than ten years of continuous technological innovation and experience accumulation, the team's R&D personnel have established a complete quality management system for CATO, and have successively obtained ISO9001, ISO17034, CNAS and other international certifications.
It has successfully passed on-site inspections from the United States, Australia, Poland, Japan and domestic pharmaceutical company customers and institutions many times, providing high-quality one-stop services for R&D and production of new drugs around the world.

More than 150 sets of equipment to ensure quality.

The emphasis on quality is the basis for our survival and development, and is the most basic requirement for the products and services we provide. CATO has established a scientific, strict and comprehensive quality prevention and assurance system in accordance with international quality standards. Through advanced testing equipment such as GC-MS, chromatograph, nuclear magnetic resonance, scanning electron microscope, and ultraviolet light, quality management is implemented into every aspect of production and operation activities such as raw materials, inventory, production, testing, sales, verification, and training, and "All actions are controlled and traceable" as the work code of conduct for CATO employees.

Over 1000 cases. Synthesize complex compounds.

Currently, CATO serves more than 500 pharmaceutical companies, biotechnology and other companies around the world. Project types cover the entire cycle from pre-clinical to commercialization stages. As of 2020, CATO has delivered more than 1,000 projects in total.
The company has core technologies in key core technology fields such as high-end fluorine chemistry, asymmetric chiral synthesis, glycoside and biological enzyme technology, and continuous microreactors.

About the company

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Whether to provide samples?

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Delivery time

Under normal circumstances, all items are in stock and will be shipped before 4 o'clock on the same day. Some products are produced to order, depending on the workshop situation and production schedule.

What is the production capacity?

At present, the company's workshop production equipment is mainly based on laboratories and pilot lines, with a maximum daily production capacity of 1.5 tons.

Can additional test indicators be added?

We can provide moisture, UV, IR, HNMR, CNMR, two-dimensional nuclear magnetic spectroscopy, optical rotation detection, elemental analysis, TGA analysis and residue analysis and other related tests to support personalized needs.

Technical direction

In the early stage, our company mainly engaged in drug impurity synthesis and standard product production, with core technologies in chirality, fluorine chemistry, and heterocycles.

Why Chem-iso’s delivery rate is guaranteed to be 99.99%

5000+

square meter R&D center

150+

China(set) of R&D equipment

150+

Fume hood

180+

R&D team

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