1. Product Overview & Specifications

Hexamethonium Chloride (CAS 60-25-3) is a quaternary ammonium compound and competitive ganglionic blocker. Widely used in research and pharmaceutical development, it inhibits nicotinic acetylcholine receptors in autonomic ganglia.

Technical Parameters

Competitive Comparison

2. Key Applications & Uses

Pharmaceutical Research

• Hypertension mechanism studies
• Autonomic nervous system modulation
• Nicotinic receptor antagonist in neuropharmacology

Experimental Medicine

• Inducing controlled hypotension in animal models
• Studying ganglionic transmission pathways

3. Usage Guidelines & Best Practices

In Vitro Protocols

For receptor binding assays: Use 10-100 μM concentration in physiological buffer. Monitor effects within 15-30 minute window.

In Vivo Administration

Rodent models: 5-20 mg/kg intravenous injection. Monitor blood pressure changes every 5 minutes for 1 hour post-administration.

4. Case Studies: Real-World Applications

Case 1: Hypertension Research

A university team used Hexamethonium Chloride to isolate sympathetic nervous system contributions to essential hypertension, achieving 92% protocol success rate.

Case 2: Neurotransmission Analysis

Diagnostic lab utilized 15 mM solutions to map cholinergic pathways in primate models, reducing experimental variability by 40% compared to previous methods.

5. Client Success Stories

Client A: University Research Team

Challenge: Needed reproducible ganglionic blockade in murine models
Solution: Custom 98% purity formulation with batch consistency testing
Outcome: 18-month study published in Journal of Neurochemistry

Client B: Pharma Developer

Challenge: Screening antihypertensive drug candidates
Solution: Bulk supply with ISO-certified analytical reports
Result: Accelerated lead compound identification by 6 months

6. Request a Quote or Custom Solution

Contact our technical team for:

• GMP-grade batches
• Custom purity specifications (95-99.9%)
• Bulk ordering discounts

Email: info@vivalr.com
Phone: (86) 15866781826

Request SDS, COA, or clinical-grade samples today.