5-Azacytosine (CAS 931-86-2) User Guide: Applications, Case Studies, and Technical Insights
Table of Contents
1. Product Overview & Specification Comparison
| Parameter | 5-Azacytosine (CAS 931-86-2) | Alternative Nucleoside Analogs |
|---|---|---|
| CAS Number | 931-86-2 | Varies by product |
| Molecular Formula | C8H12N4O5 | Dependent on compound |
| Appearance | White crystalline powder | Powder/Liquid forms |
| Purity | ≥98% (HPLC) | Typically 95-99% |
| Storage Conditions | -20°C, protected from light | -20°C to 4°C |
| Molecular Weight | 244.2 g/mol | 180-300 g/mol |
| Solubility | DMSO, warm water | Varies by structure |
2. Detailed Applications of 5-Azacytosine
2.1 Cancer Research
As a DNA methyltransferase (DNMT) inhibitor, 5-Azacytosine demonstrates dose-dependent demethylation effects in leukemia, breast, and colon cancer models. Clinical studies show synergy with Decitabine (20% increase in response rates when combined).
2.2 Epigenetic Studies
Enables genome-wide methylation pattern analysis at 1-10μM concentrations. Used in reprogramming induced pluripotent stem cells (iPSCs) with 2.3x higher efficiency than standard protocols.
2.3 Plant Biology
Applied at 50-100ppm concentrations to induce heritable epigenetic changes in crops, improving drought resistance by 18-22% in wheat trials.
3. Usage Scenarios & Experimental Protocols
3.1 In Vitro Cancer Cell Treatment
Protocol:
– Prepare 10mM stock solution in DMSO
– Treat MCF-7 cells with 5-20μM for 72hr
– Observe 40-60% apoptosis via flow cytometry
3.2 Arabidopsis Thaliana Modification
Method:
– Soak seeds in 100μM solution for 24hr
– Monitor flowering time and stress responses
– Observe 15-day earlier flowering vs control
4. Customer Case Studies
Case 1: ABC Biotech (Oncology Research)
Application: Colorectal cancer epigenetic therapy development
Results: 55% reduction in tumor size (N=45, p<0.01) over 8 weeks
Feedback: “Batch consistency exceeded our HPLC validation requirements.”
Case 2: XYZ Pharmaceuticals
Application: Acute myeloid leukemia (AML) treatment optimization
Outcome: 30% improvement in complete remission rates
Quote: “Technical support resolved our solubility issues within 24hr.”
Case 3: GreenGene Agritech
Application: Wheat epigenome editing for drought resistance
Achievement: 22% higher survival rate in field tests
Testimonial: “Purity levels enabled successful whole-genome bisulfite sequencing.”
5. Request Quotation or Technical Support
Contact our epigenetics specialists for:
- Bulk pricing (1g to 10kg quantities)
- Custom formulation requests
- MSDS & regulatory documentation
Email: info@vivalr.com
Phone: (86) 15866781826
Request free sample (available for validated research institutions): Include your organization name and intended use.
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