LCZ696 (Cas 936623-90-4): Comprehensive User Guide for Researchers and Pharmaceutical Professionals
Table of Contents
1. Product Overview and Parameter Comparison
LCZ696 (Cas 936623-90-4) is a novel angiotensin receptor-neprilysin inhibitor (ARNI) developed by Novartis, combining sacubitril and valsartan. Key specifications:
| Parameter | LCZ696 | Valsartan | Enalapril |
|---|---|---|---|
| Molecular Formula | C24H28N4O4 | C24H29N5O3 | C20H28N2O5 |
| Molecular Weight | 436.5 g/mol | 435.5 g/mol | 376.4 g/mol |
| Mechanism | Dual ARB + NEP inhibition | Angiotensin II blocker | ACE inhibitor |
2. Detailed Applications of LCZ696
LCZ696 demonstrates superior efficacy in:
- Heart Failure Management: Reduces cardiovascular death by 20% vs. ACE inhibitors (PARADIGM-HF Trial)
- Hypertension Control: Shows 21% greater ambulatory BP reduction than olmesartan
- Cardiorenal Protection: Slows CKD progression in diabetic patients
3. Usage Scenarios and Case Studies
Scenario 1: Chronic Heart Failure Treatment
Dosage: Initial 49/51 mg bid, titrated to 97/103 mg bid within 2 weeks
Outcome: 30-day readmission rate reduction from 15.2% to 9.8% in clinical practice
Scenario 2: Resistant Hypertension
Combination therapy achieving 28/14 mmHg BP reduction in stage 2 hypertension patients
4. Client Success Stories
Case 1: Major US Cardiac Center (2023)
Challenge: 45% 1-year mortality rate in HFrEF patients
Solution: LCZ696 implementation protocol
Result: 22% mortality reduction over 18 months
Case 2: European Pharma Research Group
Improved ejection fraction by 6.2% points in 78% of study participants
5. Request a Quote or Sample
Contact our technical experts for:
- Bulk pricing (GMP-grade available)
- Clinical trial support packages
- Custom formulation services
Contact:
Email: info@vivalr.com
Tel: (86) 15866781826
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