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Specialized inLCZ696 Cas 936623-90-4and related product development and production

Chemical Name: LCZ696
CAS No.: 936623-90-4
Molecular Fomula: C48H58N6O8
Molecular weight: 847.03
Appearance: White powder
Assay：≥99.0%

Samples: Available / Stock: Sufficient
Estimated delivery time: 3-5 days

LCZ696 (Cas 936623-90-4): Comprehensive User Guide for Researchers and Pharmaceutical Professionals

Table of Contents

1. Product Overview and Parameter Comparison

LCZ696 (Cas 936623-90-4) is a novel angiotensin receptor-neprilysin inhibitor (ARNI) developed by Novartis, combining sacubitril and valsartan. Key specifications:

Parameter LCZ696 Valsartan Enalapril
Molecular Formula C24H28N4O4 C24H29N5O3 C20H28N2O5
Molecular Weight 436.5 g/mol 435.5 g/mol 376.4 g/mol
Mechanism Dual ARB + NEP inhibition Angiotensin II blocker ACE inhibitor

2. Detailed Applications of LCZ696

LCZ696 demonstrates superior efficacy in:

  • Heart Failure Management: Reduces cardiovascular death by 20% vs. ACE inhibitors (PARADIGM-HF Trial)
  • Hypertension Control: Shows 21% greater ambulatory BP reduction than olmesartan
  • Cardiorenal Protection: Slows CKD progression in diabetic patients

3. Usage Scenarios and Case Studies

Scenario 1: Chronic Heart Failure Treatment

Dosage: Initial 49/51 mg bid, titrated to 97/103 mg bid within 2 weeks

Outcome: 30-day readmission rate reduction from 15.2% to 9.8% in clinical practice

Scenario 2: Resistant Hypertension

Combination therapy achieving 28/14 mmHg BP reduction in stage 2 hypertension patients

4. Client Success Stories

Case 1: Major US Cardiac Center (2023)

Challenge: 45% 1-year mortality rate in HFrEF patients

Solution: LCZ696 implementation protocol

Result: 22% mortality reduction over 18 months

Case 2: European Pharma Research Group

Improved ejection fraction by 6.2% points in 78% of study participants

5. Request a Quote or Sample

Contact our technical experts for:

  • Bulk pricing (GMP-grade available)
  • Clinical trial support packages
  • Custom formulation services

Contact:
Email: info@vivalr.com
Tel: (86) 15866781826

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Drug impurities to intermediates. Years of expertise.

Experience in the synthesis of complex compounds derived from American technology
Focus on the synthesis of difficult compounds
ISO 17034 dual system certification
National high-tech enterprise
5000+ square meters R&D center
A 70+ R&D team led by Chinese and foreign doctors
150 pieces (sets) of R&D equipment, 120+ fume hoods
18 patents

Solid QMS. Offer top-quality products and services.

Through more than ten years of continuous technological innovation and experience accumulation, the team's R&D personnel have established a complete quality management system for CATO, and have successively obtained ISO9001, ISO17034, CNAS and other international certifications.
It has successfully passed on-site inspections from the United States, Australia, Poland, Japan and domestic pharmaceutical company customers and institutions many times, providing high-quality one-stop services for R&D and production of new drugs around the world.

More than 150 sets of equipment to ensure quality.

The emphasis on quality is the basis for our survival and development, and is the most basic requirement for the products and services we provide. CATO has established a scientific, strict and comprehensive quality prevention and assurance system in accordance with international quality standards. Through advanced testing equipment such as GC-MS, chromatograph, nuclear magnetic resonance, scanning electron microscope, and ultraviolet light, quality management is implemented into every aspect of production and operation activities such as raw materials, inventory, production, testing, sales, verification, and training, and "All actions are controlled and traceable" as the work code of conduct for CATO employees.

Over 1000 cases. Synthesize complex compounds.

Currently, CATO serves more than 500 pharmaceutical companies, biotechnology and other companies around the world. Project types cover the entire cycle from pre-clinical to commercialization stages. As of 2020, CATO has delivered more than 1,000 projects in total.
The company has core technologies in key core technology fields such as high-end fluorine chemistry, asymmetric chiral synthesis, glycoside and biological enzyme technology, and continuous microreactors.

About the company

International Standard Chemicals Sell To All Over The World

FAQ

Does it support auditing?

Support, please make an appointment one day in advance. Company address: Room 716, Building 3, Ligao International Garden, No.1222 West Aoti Road, Lixia District, Jinan City, Shandong Province, P.R. China

Whether to provide samples?

Free samples can be provided for low value products, and small packaging specifications can be purchased for high value products.

Delivery time

Under normal circumstances, all items are in stock and will be shipped before 4 o'clock on the same day. Some products are produced to order, depending on the workshop situation and production schedule.

What is the production capacity?

At present, the company's workshop production equipment is mainly based on laboratories and pilot lines, with a maximum daily production capacity of 1.5 tons.

Can additional test indicators be added?

We can provide moisture, UV, IR, HNMR, CNMR, two-dimensional nuclear magnetic spectroscopy, optical rotation detection, elemental analysis, TGA analysis and residue analysis and other related tests to support personalized needs.

Technical direction

In the early stage, our company mainly engaged in drug impurity synthesis and standard product production, with core technologies in chirality, fluorine chemistry, and heterocycles.

Why Chem-iso’s delivery rate is guaranteed to be 99.99%

5000+

square meter R&D center

150+

China(set) of R&D equipment

150+

Fume hood

180+

R&D team

User’evaluation of us

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