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Specialized inBempedoic Acid CAS 738606-46-7and related product development and production

Chemical Name: Bempedoic Acid
Synonyms: ESP 55016; ETC 1002
CAS No.: 738606-46-7
Molecular Fomula: C19H36O5
Molecular weight: 344.49
Appearance: White powder
Assay: 99%

Samples: Available / Stock: Sufficient
Estimated delivery time: 3-5 days

Comprehensive Guide to Bempedoic Acid (CAS 738606-46-7)

Table of Contents

1. Product Overview & Specifications

Bempedoic Acid (CAS 738606-46-7) is a first-in-class ATP citrate lyase inhibitor with the following technical parameters:

Parameter Specification
Chemical Name 8-Hydroxy-2,2,14,14-tetramethylpentadecanedioic acid
Molecular Formula C19H36O5
Molecular Weight 344.49 g/mol
Appearance White to off-white crystalline powder
Solubility Practically insoluble in water (≤0.1 mg/mL)
Storage Conditions 2-8°C in airtight containers

2. Key Applications & Therapeutic Uses

Primary clinical applications include:

  • Treatment of heterozygous familial hypercholesterolemia (HeFH)
  • Management of atherosclerotic cardiovascular disease (ASCVD)
  • Adjunct therapy to maximally tolerated statins
  • Alternative for statin-intolerant patients

3. Clinical Usage Scenarios

3.1 Primary Hyperlipidemia Management

Dosage: 180 mg oral tablet once daily

3.2 Combination Therapy Protocol

Typical combinations with:

  • Ezetimibe (dual mechanism therapy)
  • PCSK9 inhibitors in high-risk patients

4. Real-World Case Studies

4.1 Cardiovascular Clinic - Boston, USA

Challenge: 62-year-old male with statin-induced myalgia (LDL-C: 145 mg/dL)

Solution: Bempedoic Acid + Ezetimibe combination

Outcome: LDL-C reduced to 78 mg/dL within 12 weeks

4.2 EU Cardiology Center Case

Patient Profile: Post-MI patient with multiple drug intolerances

Regimen: Monotherapy at 180 mg/day

Result: 28% LDL-C reduction sustained over 6 months

5. Technical Comparison with Alternatives

Parameter Bempedoic Acid Atorvastatin Ezetimibe
Mechanism ACL inhibitor HMG-CoA inhibitor NPC1L1 inhibitor
LDL Reduction 18-25% 30-50% 15-20%
Muscle AE Rate 1.2% 5-10% 0.8%

6. Procurement Guidance

For commercial inquiries or technical specifications:

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Drug impurities to intermediates. Years of expertise.

Experience in the synthesis of complex compounds derived from American technology
Focus on the synthesis of difficult compounds
ISO 17034 dual system certification
National high-tech enterprise
5000+ square meters R&D center
A 70+ R&D team led by Chinese and foreign doctors
150 pieces (sets) of R&D equipment, 120+ fume hoods
18 patents

Solid QMS. Offer top-quality products and services.

Through more than ten years of continuous technological innovation and experience accumulation, the team's R&D personnel have established a complete quality management system for CATO, and have successively obtained ISO9001, ISO17034, CNAS and other international certifications.
It has successfully passed on-site inspections from the United States, Australia, Poland, Japan and domestic pharmaceutical company customers and institutions many times, providing high-quality one-stop services for R&D and production of new drugs around the world.

More than 150 sets of equipment to ensure quality.

The emphasis on quality is the basis for our survival and development, and is the most basic requirement for the products and services we provide. CATO has established a scientific, strict and comprehensive quality prevention and assurance system in accordance with international quality standards. Through advanced testing equipment such as GC-MS, chromatograph, nuclear magnetic resonance, scanning electron microscope, and ultraviolet light, quality management is implemented into every aspect of production and operation activities such as raw materials, inventory, production, testing, sales, verification, and training, and "All actions are controlled and traceable" as the work code of conduct for CATO employees.

Over 1000 cases. Synthesize complex compounds.

Currently, CATO serves more than 500 pharmaceutical companies, biotechnology and other companies around the world. Project types cover the entire cycle from pre-clinical to commercialization stages. As of 2020, CATO has delivered more than 1,000 projects in total.
The company has core technologies in key core technology fields such as high-end fluorine chemistry, asymmetric chiral synthesis, glycoside and biological enzyme technology, and continuous microreactors.

About the company

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FAQ

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Whether to provide samples?

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Delivery time

Under normal circumstances, all items are in stock and will be shipped before 4 o'clock on the same day. Some products are produced to order, depending on the workshop situation and production schedule.

What is the production capacity?

At present, the company's workshop production equipment is mainly based on laboratories and pilot lines, with a maximum daily production capacity of 1.5 tons.

Can additional test indicators be added?

We can provide moisture, UV, IR, HNMR, CNMR, two-dimensional nuclear magnetic spectroscopy, optical rotation detection, elemental analysis, TGA analysis and residue analysis and other related tests to support personalized needs.

Technical direction

In the early stage, our company mainly engaged in drug impurity synthesis and standard product production, with core technologies in chirality, fluorine chemistry, and heterocycles.

Why Chem-iso’s delivery rate is guaranteed to be 99.99%

5000+

square meter R&D center

150+

China(set) of R&D equipment

150+

Fume hood

180+

R&D team

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