Chemical Name: Benzylmagnesium Chloride
CAS No.: 6921-34-2
Molecular Formula: C7H7ClMg
Molecular Weight: 150.89
Appearance: Liquid
Parameter | Benzylmagnesium Chloride | Phenylmagnesium Bromide | Allylmagnesium Chloride |
---|---|---|---|
CAS Number | 6921-34-2 | 100-58-3 | 2622-05-1 |
Molecular Formula | C7H7ClMg | C6H5BrMg | C3H5ClMg |
Concentration (Typical) | 1.0M in THF | 2.0M in Diethyl Ether | 0.8M in THF |
Reactivity Profile | Moderate nucleophilicity | High electrophile affinity | Radical reaction compatibility |
Preferred for synthesizing antihistamine precursors due to superior benzyl group transfer efficiency at low temperatures (-30°C to 0°C).
Enables controlled benzylation in polystyrene modification processes with 92-97% functionalization rates.
Used in 3-step benzylation process achieving 84% overall yield (GMP batch scale).
Enabled 40% reduction in catalyst loading compared to alternative Grignard reagents.
Annual consumption: 850L
Application: Continuous flow synthesis of benzylated protease inhibitors
Usage: Monthly 200kg
Achievement: Developed flame-retardant polymers meeting UL94 V-0 standard
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