N-(Trimethylsilyl)imidazole CAS 18156-74-6: Comprehensive Guide
Table of Contents
Product Overview & Specifications
| Parameter | Specification |
|---|---|
| CAS Number | 18156-74-6 |
| Molecular Formula | C6H12N2Si |
| Molecular Weight | 156.26 g/mol |
| Appearance | Colorless to pale yellow liquid |
| Purity | ≥98% (GC) |
| Density | 0.97 g/cm³ at 25°C |
| Boiling Point | 93-95°C at 10 mmHg |
Applications & Use Cases
Primary Applications
- Silylation reagent for hydroxyl and amino group protection
- Intermediate in organosilicon compound synthesis
- Catalyst in polyurethane production
Industry-Specific Uses
| Industry | Application Detail |
|---|---|
| Pharmaceuticals | Protecting group in nucleoside analog synthesis |
| Electronics | Surface modification of silica-based materials |
| Polymers | Crosslinking agent in silicone rubber production |
Performance Comparison
| Reagent | Reaction Rate | Stability | Cost Efficiency |
|---|---|---|---|
| N-(Trimethylsilyl)imidazole | High | Excellent | Medium |
| HMDS | Medium | Good | High |
| BSTFA | Very High | Poor | Low |
Industry-Specific Usage Scenarios
Pharmaceutical Synthesis
Used in protection of hydroxyl groups during antiviral drug intermediate synthesis, demonstrating 92% yield improvement compared to traditional methods.
Advanced Material Engineering
Implemented in surface functionalization of mesoporous silica nanoparticles for targeted drug delivery systems.
Customer Case Studies
Case 1: Major Pharma Company (EU-based)
- Application: Remdesivir intermediate production
- Result: 40% reduction in side reactions
- Throughput: 2.3 metric tons/month
Case 2: Electronics Manufacturer (Japan)
- Application: Semiconductor surface treatment
- Result: 15% improvement in adhesion properties
- Consumption: 850 kg/quarter
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