1,1′-Thiocarbonyldiimidazole (CAS 6160-65-2): Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
1,1′-Thiocarbonyldiimidazole (CAS 6160-65-2) is a specialized organosulfur compound with the molecular formula C7H6N4S. This yellow crystalline solid serves as a high-performance thiocarbonyl transfer agent in organic synthesis.
| Parameter | Specification |
|---|---|
| CAS Number | 6160-65-2 |
| Molecular Weight | 194.22 g/mol |
| Purity | ≥98% (HPLC) |
| Melting Point | 142-145°C |
| Solubility | DCM, THF, DMF |
| Storage | 2-8°C (desiccated) |
2. Key Applications & Use Cases
2.1 Pharmaceutical Intermediate Synthesis
Enables efficient preparation of thioamides and thiourea derivatives through nucleophilic substitution reactions. Typical yield improvement: 15-20% vs. traditional methods.
2.2 Peptide Modification
Faculates selective introduction of thiocarbonyl groups into peptide chains under mild conditions (pH 6.5-7.5, 25-40°C).
3. Performance Comparison
| Reagent | Reaction Time | Yield | Byproducts |
|---|---|---|---|
| TCI (6160-65-2) | 2-4 hrs | 85-92% | <3% |
| Thiophosgene | 6-8 hrs | 65-75% | 15-20% |
| Lawesson’s Reagent | 12-24 hrs | 70-80% | 5-8% |
4. Industry Case Studies
4.1 Antiviral Drug Development
Used in synthesis of Remdesivir intermediates, achieving 89% conversion rate at 50°C in DMF solvent system.
5. Client Success Stories
5.1 Top-10 Pharma Company (Confidential)
Application: Kinase inhibitor development
Result: Reduced reaction steps from 5 to 2 in lead compound optimization
5.2 Advanced Material Manufacturer
Application: Conductive polymer modification
Outcome: Achieved 95% conductivity improvement in PEDOT derivatives
6. Request Customized Solutions
Contact our technical team for formulation support or bulk inquiries:
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Tel: (86) 15866781826
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