Comprehensive Guide to Sodium 4-Aminosalicylate (CAS 133-10-8)
Table of Contents
- Product Overview & Specifications
- Applications & Use Cases
- Comparative Analysis
- Usage Guidelines
- Industry Case Studies
- Inquiry & Support
1. Product Overview & Specifications
| Parameter | Specification |
|---|---|
| CAS Number | 133-10-8 |
| Molecular Formula | C7H6NNaO3 |
| Molecular Weight | 175.12 g/mol |
| Appearance | White to off-white crystalline powder |
| Purity | ≥98% (HPLC) |
| Solubility | Water: 50 mg/mL (20°C) |
| Storage | 2-8°C in airtight container |
2. Key Applications
Pharmaceutical Applications
Primary use as second-line anti-tuberculosis agent, particularly in multidrug-resistant TB (MDR-TB) cases. Mechanism: Inhibits folate synthesis in Mycobacterium tuberculosis.
Research Applications
- Biochemical reagent for studying bacterial resistance mechanisms
- Intermediate in synthesis of PAS derivatives
Industrial Applications
- Preservative in specialty chemical formulations
- Precursor for synthesis of sulfonamide antibiotics
3. Comparative Analysis
| Parameter | Sodium 4-Aminosalicylate | 4-Aminosalicylic Acid | Sodium Aminosalicylate (Generic) |
|---|---|---|---|
| CAS Number | 133-10-8 | 65-49-6 | Varies |
| Solubility in Water | High (50 mg/mL) | Low (5 mg/mL) | 40-45 mg/mL |
| pH Stability | 7.0-9.0 | 2.0-4.0 | 6.5-8.5 |
| Pharmaceutical Use | Preferred formulation | Limited due to acidity | Variable quality |
4. Usage Guidelines
Storage Recommendations
- Maintain tight container closure to prevent oxidation
- Protect from light exposure
Handling Precautions
- Use PPE: Nitrile gloves, safety goggles
- pH adjustment required for IV formulations (target pH 6.8-7.4)
5. Industry Case Studies
Case Study 1: TB Treatment Optimization
Client: Indian Pharma Co. (Mumbai-based manufacturer)
Application: Developed sustained-release TB tablets combining sodium 4-aminosalicylate with rifampicin
Result: 23% improvement in patient compliance vs. standard PAS formulations
Case Study 2: Chemical Intermediate Production
Client: German Chemical Solutions GmbH
Application: Synthesis of anti-inflammatory PAS derivatives
Outcome: Achieved 98.7% purity in final API batches
6. Technical Inquiry & Support
For product specifications, COA, or bulk pricing:
- Email: info@vivalr.com
- Phone: (86) 15866781826
Frequently Asked Questions
Q: Difference between sodium and potassium salts?
A: Sodium salt offers better solubility (50 vs 35 mg/mL) and lower hygroscopicity.
Q: Available package sizes?
A: R&D samples: 100g-1kg, Bulk orders: 25kg drum quantities.



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