Fosfomycin (CAS 23155-02-4): Comprehensive Technical Profile
Table of Contents
1. Chemical Properties & Specifications
| Parameter | Specification |
|---|---|
| CAS Number | 23155-02-4 |
| Molecular Formula | C3H7O4P |
| Molecular Weight | 138.059 g/mol |
| Appearance | White hygroscopic crystalline powder |
| Melting Point | 94°C |
| Boiling Point | 342.65°C at 760 mmHg |
| Density | 1.561 g/cm³ |
| Solubility | Freely soluble in water (with exothermic reaction) |
Structural Features:
SMILES: OP((C@H)1O(C@H)1C)(O)=O
InChIKey: YMDXZJFXQJVXBF-STHAYSLISA-N
2. Pharmacological Mechanism
This broad-spectrum bactericidal agent demonstrates unique action through:
- Irreversible inhibition of UDP-N-acetylglucosamine enolpyruvyl transferase (MurA)
- Disruption of peptidoglycan precursor synthesis in cell wall formation
- Synergistic activity with β-lactams and aminoglycosides
- Effective CNS penetration (CSF concentration: 20-30% serum levels)
3. Therapeutic Applications
Clinical Indications:
- Complicated UTIs (including pyelonephritis)
- Multidrug-resistant infections (XDR/PDR Gram-negative pathogens)
- Surgical prophylaxis in transrectal prostate biopsy
- Off-label use in osteomyelitis and CNS infections
Spectrum of Activity:
| Microorganism | MIC90 (μg/mL) |
|---|---|
| E. coli (ESBL+) | 8-32 |
| K. pneumoniae (CRE) | 64-128 |
| P. aeruginosa | 128-256 |
| Enterococcus spp. | 16-64 |
4. Quality Standards
| Grade | Potency | Impurities | Packaging |
|---|---|---|---|
| Pharmaceutical | ≥700 IU/mg | ≤0.5% related substances | Double PE bags (1kg/5kg) |
| Research | ≥95% HPLC | EP/USP compliance | Amber glass vials (10mg-10g) |
5. Regulatory Information
- HS Code: 29319090 (EU Harmonized System)
- Storage: 2-8°C protected from light
- Stability: 36 months in original packaging
- Transport: Non-hazardous (exempt from IATA/ADR)
For technical specifications or COA requests:
Email: info@vivalr.com
Tel: (86) 15866781826
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