Madecassoside (CAS 34540-22-2): Technical Specifications, Applications, and Case Studies
Table of Contents
1. Key Specifications
| Parameter | Value |
|---|---|
| CAS Number | 34540-22-2 |
| Molecular Formula | C48H78O20 |
| Molecular Weight | 975.12 g/mol |
| Purity | ≥98% (HPLC) |
| Appearance | White to off-white crystalline powder |
| Solubility | Soluble in methanol, DMSO; limited water solubility |
| Storage | -20°C (2-year stability in dry form) |
2. Functional Applications
Core Biological Activities:
- Anti-inflammatory: Inhibits NF-κB and p38 MAPK signaling pathways
- Antioxidant: Enhances Nrf2-mediated cellular defense mechanisms
- Anti-apoptotic: Reduces caspase activation in neural cells
- Vasorelaxant: Modulates calcium signaling in vascular smooth muscle
- Dermatological: Promotes fibroblast proliferation and collagen synthesis
3. Research and Clinical Applications
Validated Therapeutic Effects:
- Wound Healing: Demonstrated 40% acceleration in epithelialization in burn models
- Neuroprotection: Reduced oxidative stress in Alzheimer’s disease cellular models
- Cardiovascular: Showed 35% vasodilation in pre-contracted rat aortic rings
- Dermatology: Effective in psoriasis models through IL-6/IL-8 suppression
- Dental: Inhibited LPS-induced apoptosis in human gingival fibroblasts
4. Industry Use Cases
Case 1: Advanced Drug Delivery Systems
Application: PEG-PCL-PEG modified liposomes for transdermal delivery
Outcome: Achieved 3.2x increase in skin permeation vs. free compound
Case 2: Cosmetic Formulation Development
Application: Anti-aging serum with 0.5% Madecassoside
Result: 28% reduction in wrinkle depth after 8-week clinical trial
Case 3: Cardiovascular Research
Study: Angiotensin II resistance modulation
Finding: Showed selective inhibition of intracellular Ca2+ release pathways
5. Storage & Ordering
Packaging Options:
- Research Scale: 10mg-200mg (lyophilized powder)
- Bulk Supply: Custom quantities up to kilogram scale
Ordering Information:
Contact our technical team for purity verification documents and formulation support:
Email: info@vivalr.com
Tel: (86) 15866781826
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