2-(Methylsulfonyl)benzothiazole CAS 7144-49-2: Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
| Parameter | Specification |
|---|---|
| CAS Number | 7144-49-2 |
| Molecular Formula | C8H7NO2S2 |
| Molecular Weight | 213.28 g/mol |
| Appearance | White to off-white crystalline powder |
| Melting Point | 148-152°C |
| Solubility | Soluble in DMSO, DMF; sparingly soluble in water |
2. Key Applications & Industrial Uses
Pharmaceutical Intermediate
Used in synthesis of kinase inhibitors and antimicrobial agents due to its electron-deficient benzothiazole core.
Agrochemical Production
Key precursor for fungicides targeting Botrytis cinerea in crop protection formulations.
Polymer Chemistry
Enhances vulcanization efficiency in rubber manufacturing (accelerator MBTS replacement).
3. Performance Comparison with Alternatives
| Property | 2-(Methylsulfonyl)benzothiazole | 2-Mercaptobenzothiazole (MBT) | Benzothiazole disulfide (MBTS) |
|---|---|---|---|
| Thermal Stability | Excellent (>300°C) | Good (250°C) | Moderate (200°C) |
| Reactivity | Controllable sulfone activation | High thiol reactivity | Moderate disulfide cleavage |
4. Practical Use Cases
Case A: Antifungal Drug Synthesis
Used in 3-step synthesis of Voriconazole analogs (yield improvement: 22% vs traditional methods).
Case B: Crop Protection Formulation
40% reduction in phytotoxicity observed in wheat fungicide trials compared to MBT-based products.
5. Verified Customer Success Stories
PharmaTech Solutions (Germany)
Achieved 99.5% purity in c-Met inhibitor production through optimized coupling reactions.
AgroShield Ltd (USA)
Developed delayed-action fungicide with 60-day soil persistence using our sulfone derivative.
6. Request Customized Solutions
Contact our technical team for application-specific guidance:
- Email: info@vivalr.com
- Tel: (86) 15866781826
Available services:
- Bulk quantities (25kg drums to ton-scale)
- Custom functionalization (e.g., fluorinated derivatives)
- Regulatory support (REACH, TSCA compliance)
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