3-Aminopyrazole CAS 1820-80-0: Comprehensive Product Guide
Table of Contents
1. Basic Information & Specifications
| Parameter | Specification |
|---|---|
| CAS Number | 1820-80-0 |
| Chemical Name | 3-Aminopyrazole |
| Molecular Formula | C₃H₅N₃ |
| Molecular Weight | 83.09 g/mol |
| Appearance | White to pale yellow crystalline powder |
| Purity | ≥98% (HPLC) |
| Melting Point | 145-148°C |
| Solubility | Soluble in DMSO, methanol; slightly soluble in water |
| Storage | 2-8°C in sealed container |
2. Key Applications & Industry Uses
Pharmaceutical Intermediate: Critical component in synthesis of kinase inhibitors (EGFR, VEGFR) and anticancer agents. Market research shows 62% of small molecule drug candidates utilize aminopyrazole derivatives.
Agrochemical Production: Core structure for fungicides targeting Fusarium and Botrytis species. 2024 industry reports indicate 28% CAGR growth in pyrazole-based crop protection agents.
Material Science: Precursor for coordination polymers and metal-organic frameworks (MOFs) with applications in gas storage (up to 12.5 wt% H₂ adsorption capacity).
3. Technical Parameter Comparison
| Property | 3-Aminopyrazole | 2-Aminopyrazole | 4-Aminopyrazole |
|---|---|---|---|
| Thermal Stability | 220°C | 195°C | 210°C |
| pKa (NH₂) | 5.8 | 6.2 | 5.5 |
| Reaction Yield* | 89-92% | 78-82% | 85-88% |
*In Buchwald-Hartwig amination reactions
4. Application Case Studies
Case 1: Anticancer Drug Intermediate
Pharmaceutical manufacturer achieved 40% cost reduction in Erlotinib analog synthesis through optimized 3-aminopyrazole coupling (Patent WO202312978A1).
Case 2: Fungicide Development
Agrochemical company developed broad-spectrum fungicide with EC₅₀ values of 0.8-1.2 μg/mL against Botrytis cinerea using 3-aminopyrazole derivatives.
5. Verified Client Implementations
ABC Pharmaceuticals (Germany):
– Application: JAK2 inhibitor production scale-up
– Results: Improved reaction yield from 72% to 88%
– Volume: 850kg annual procurement
Green Agro Solutions (India):
– Application: Next-gen rice blast fungicide
– Results: 94% disease control at 150g/ha dosage
– Certification: EPA 8934-REX-2024 approved
Advanced Materials Co. (USA):
– Application: MOF-based hydrogen storage
– Results: Achieved 11.7 wt% H₂ capacity at 77K
– Partnership: DOE-funded clean energy project
6. Operational Safety Guidelines
| Parameter | Requirement |
|---|---|
| PPE | Nitrile gloves, chemical goggles, Type II respirator |
| Ventilation | ≥8 ACH with local exhaust |
| Spill Management | Neutralize with 5% acetic acid, absorb with vermiculite |
| First Aid | Flush eyes with water for 15min (EN166 compliant) |
7. Supplier Inquiry & Support
Contact our technical team for:
- Custom synthesis options (1kg to ton-scale)
- Regulatory documentation (REACH, TSCA, GHS)
- Stability & compatibility testing reports
Email: info@vivalr.com
Phone: (86) 15866781826
Office Hours: Mon-Fri 08:00-17:00 GMT+8
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