Acetonitrile (CAS 75-05-8): Technical Guide for Industrial Applications
Table of Contents
1. Product Overview & Specifications
Chemical Name: Acetonitrile (Methyl Cyanide)
CAS No.: 75-05-8
Molecular Formula: C2H3N
Molecular Weight: 41.05 g/mol
Physical Properties:
| Property | Value |
|---|---|
| Appearance | Colorless liquid |
| Boiling Point | 81.6°C |
| Melting Point | -45°C |
| Density | 0.7857 g/cm³ |
| Flash Point | 12.8°C (closed cup) |
| Solubility | Miscible with water, ethanol, ether |
Commercial Grade Comparison:
| Supplier | Purity | Packaging | Key Feature |
|---|---|---|---|
| Shanghai Meryer | ≥99% | 160 kg/drum | Pharmaceutical grade |
| Macklin | ≥99.8% | 5 mL vials | GC Standard grade |
| Aladdin | ≥99.5% | 500 mL – 2.5 L | ACS certified |
2. Key Applications & Industrial Uses
Pharmaceutical Manufacturing
Primary solvent for synthesizing vitamin B1, cortisone derivatives, and antibiotic intermediates. Enables high-purity crystallization processes.
Petrochemical Processing
Preferred extractant for butadiene purification and acrylonitrile production. Enables selective separation in C4 hydrocarbon streams.
Analytical Chemistry
HPLC/UPLC mobile phase component with UV transparency down to 200 nm. Certified grades meet USP/EP specifications for sensitive detection.
Specialty Chemicals
Reaction medium for synthesizing nitrogen-containing compounds, pesticides, and synthetic dyes. Compatible with Grignard and Wittig reactions.
3. Operational Guidelines & Case Studies
Case 1: Pharmaceutical Intermediate Purification
Challenge: Remove polar impurities from steroid API
Solution: 85% acetonitrile/water mixture achieved 99.7% purity
Result: Reduced processing time by 40% vs. methanol-based systems
Case 2: Polymer Synthesis
Challenge: Control molecular weight distribution in polyacrylonitrile
Solution: 0.5% acetonitrile additive in DMF solvent
Result: Achieved polydispersity index (PDI) of 1.12
4. Client Success Stories
Shanghai Meryer Chemical Technology
Application: Vitamin A acetate synthesis
Volume: 12 MT/month
Feedback: “Consistent anhydrous grade (<50 ppm H2O) ensured reaction yield stability”
Jinan Century Tongda Chemical
Application: Butadiene extraction
Volume: 80 drums/month
Feedback: “99.9% purity reduced downstream distillation costs by 18%”
Shanghai Aladdin Biochemical
Application: HPLC mobile phase production
Volume: 5,000 L/quarter
Feedback: “UV-grade solvent improved detection limits for pesticide analysis”
5. Contact for Custom Solutions
Certified Buyers Only: Valid hazardous materials license required
Bulk Order Support: 160 kg drum to ISO tank quantities available
Technical Consultation: Our chemists optimize solvent systems for your process
Email: info@vivalr.com
Phone: (86) 15866781826
Note: All shipments comply with GB 15603-2022 safety regulations. SDS available upon request.
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