RINK AMIDE AM RESIN CAS 183599-10-2: Comprehensive User Guide
Table of Contents
- Product Overview & Specifications
- Key Applications
- Operational Guidelines
- Industry Case Studies
- Contact for Technical Consultation
1. Product Specifications & Comparative Analysis
| Parameter | Rink Amide AM Resin | Standard AM Resin | Wang Resin |
|---|---|---|---|
| Loading Capacity | 0.4-0.8 mmol/g | 0.3-0.6 mmol/g | 0.5-0.7 mmol/g |
| Particle Size | 100-200 mesh | 75-150 mesh | 100-300 mesh |
| Swelling Volume | 5-7 mL/g (DCM) | 4-6 mL/g | 3-5 mL/g |
| Stability | pH 1-12 | pH 2-10 | pH 3-9 |
2. Core Applications
2.1 Solid-Phase Peptide Synthesis (SPPS)
Enables efficient C-terminal amide formation in Fmoc/t-Bu strategies, particularly effective for:
- Difficult sequence peptides (e.g., hydrophobic clusters)
- Cyclic peptide construction
- Post-synthetic modifications
2.2 Combinatorial Chemistry
Preferred matrix for:
- Parallel synthesis of compound libraries
- DNA-encoded chemical library production
- High-throughput screening preparations
3. Operational Protocol
3.1 Storage & Handling
Optimal storage conditions: 2-8°C in sealed container with desiccant
3.2 Synthesis Workflow
- Pre-swelling: 30 min in DMF/DCM (3:1)
- Fmoc deprotection: 20% piperidine/DMF (2×5 min)
- Coupling: 3×1 hr with 3 eq amino acid/HATU/DIEA
- Final cleavage: TFA/H2O/TIS (95:2.5:2.5) 2hr
4. Verified Application Cases
Case 1: Pharmaceutical Development
Client: Top 10 Global Pharma Company
Application: GLP-1 Analog Production
Result: 92% purity achieved in 15-mer peptide
Case 2: Research Institution
Client: MIT Chemical Biology Lab
Application: PROTAC Molecule Library
Output: 1,200 novel compounds synthesized
Case 3: Biotech Startup
Client: NextGen Bio Therapeutics
Application: Antibody-Drug Conjugates
Yield Improvement: 40% vs traditional methods
5. Technical Consultation
For batch-specific specifications or custom requirements:
Email: info@vivalr.com
Tel: (86) 15866781826
Request Form
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