Diethyl L-Glutamate Hydrochloride CAS 1118-89-4

Diethyl L-glutamate Hydrochloride (CAS 1118-89-4) Ultimate Product Guide

Table of Contents

• 1. Product Specifications & Comparative Analysis
• 2. Industrial Applications & Functional Mechanisms
• 3. Operational Protocols & Handling Guidelines
• 4. Verified Application Case Studies
• 5. Client Implementation Scenarios
• 6. Expert Consultation & Technical Support

1. Product Specifications & Comparative Analysis

2. Industrial Applications & Functional Mechanisms

Pharmaceutical Synthesis: Critical intermediate in nootropic drugs production including aniracetam and brivaracetam. Enables precise stereochemical control in CNS-active compounds.

Biochemical Research: Chiral building block for peptide synthesis and neurotransmitter studies. Particularly valuable in NMDA receptor modulation research.

Industrial Catalysis: Serves as asymmetric catalyst in enantioselective Mannich reactions (up to 92% ee achieved).

3. Operational Protocols & Handling Guidelines

Storage Conditions: Maintain at 2-8°C in airtight containers with nitrogen blanket. Shelf life: 36 months when unopened.

Reconstitution: Use deoxygenated ethanol-water (7:3 v/v) for optimal solubility. Avoid phosphate buffers due to precipitation risks.

Safety Profile: Non-flammable but hygroscopic. Use NIOSH-approved respirators when handling powders.

4. Verified Application Case Studies

Case 1: European Pharma Manufacturer (2023)
Achieved 22% yield improvement in racetam derivative synthesis through optimized diethyl ester protection strategy.

Case 2: US Research Consortium (2022)
Developed novel Alzheimer’s drug candidates using our HCl salt formulation for enhanced blood-brain barrier penetration.

5. Client Implementation Scenarios

Client A: Top-10 Global CRO
Annual consumption: 850kg
Application: High-throughput screening of neurological compounds
Outcome: Reduced chiral separation costs by 40%

Client B: Japanese API Producer
Batch size: 200-300kg
Process: Continuous flow synthesis optimization
Benefit: Achieved 99.7% chiral purity consistently

6. Expert Consultation & Technical Support

Contact our chemistry specialists for:

• Custom synthesis scale-up protocols
• Regulatory compliance documentation (EDMF, CEP)
• Stability studies data packages

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