4-Aminotoluene-3-sulfonic Acid (CAS 88-44-8): Comprehensive User Guide
Table of Contents
1. Product Overview and Specifications
4-Aminotoluene-3-sulfonic Acid (CAS 88-44-8), also known as 4-Amino-m-toluenesulfonic acid, is an aromatic sulfonic acid derivative with the molecular formula C7H9NO3S. Key technical parameters include:
| Parameter | Specification |
|---|---|
| Appearance | White to off-white crystalline powder |
| Purity | ≥99% (HPLC) |
| Melting Point | 280-285°C (dec.) |
| Solubility | Soluble in alkaline solutions, sparingly soluble in water |
| Storage | 2-8°C in airtight container |
2. Key Applications and Industrial Uses
2.1 Dye Intermediate
Primary use as a coupling component in azo dye synthesis for textiles and paper industries. Enables production of light-fast yellow and orange hues.
2.2 Pharmaceutical Synthesis
Critical intermediate for sulfonamide drugs and specialty APIs. Used in synthesis of COX-2 inhibitors and antimicrobial agents.
3. Parameter Comparison with Similar Compounds
| Compound | CAS | Reactivity | Thermal Stability |
|---|---|---|---|
| 4-Aminotoluene-3-sulfonic Acid | 88-44-8 | Moderate | High (>250°C) |
| 2-Aminobenzenesulfonic Acid | 88-21-1 | High | Moderate |
4. Step-by-Step Usage Guidelines
4.1 Dye Manufacturing Process
- Prepare 5% NaOH solution at 40°C
- Dissolve compound at 1:5 molar ratio
- Maintain pH 8-9 during diazotization
5. Real-World Customer Case Studies
Case 1: European Dyestuff Manufacturer
Challenge: Needed replacement for carcinogenic benzidine-based dyes
Solution: Implemented CAS 88-44-8 in new eco-friendly dye line
Result: Achieved REACH compliance + 18% production efficiency gain
Case 2: Asian API Producer
Challenge: Impurities in sulfa drug intermediate
Solution: Upgraded to 99.5% purity grade
Result: Reduced purification steps by 40%
6. Request a Quote or Technical Support
Contact our chemistry experts for:
- Custom purity grades (95%-99.9%)
- Bulk pricing (25kg drum quantities)
- Regulatory documentation support
Email: info@vivalr.com
Tel: (86) 15866781826



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