4,7-Dibromo-5,6-dinitrobenzo[c][1,2,5]thiadiazole (CAS 76186-72-6) Comprehensive User Guide
Table of Contents
1. Product Overview and Parameter Comparison
Key Specifications
| Parameter | Value |
|---|---|
| CAS Number | 76186-72-6 |
| Molecular Formula | C₆HBr₂N₄O₄S |
| Molecular Weight | 411.96 g/mol |
| Appearance | Yellow crystalline powder |
| Purity | ≥98% (HPLC) |
Comparative Analysis
| Feature | 4,7-Dibromo Derivative | Standard Benzo[c]thiadiazole |
|---|---|---|
| Electron Deficiency | High (nitro/bromo groups) | Moderate |
| Thermal Stability | Up to 250°C | 200°C |
| Solubility | DMSO, DMF | THF, Chloroform |
2. Detailed Applications and Use Cases
Core Applications
- Organic Electronics: Key building block for n-type semiconductors in OLED displays
- Pharmaceutical Intermediates: Synthesis of kinase inhibitors in cancer research
- Coordination Chemistry: Ligand precursor for transition metal complexes
Operational Workflow
Typical reaction protocol for Suzuki-Miyaura coupling:
- Charge 1.0 mmol of 4,7-dibromo-5,6-dinitrobenzo[c][1,2,5]thiadiazole in anhydrous DMF
- Add 2.2 mmol arylboronic acid under nitrogen atmosphere
- Catalyze with Pd(PPh₃)₄ (0.05 equiv) at 80°C for 12h
- Isolate product via column chromatography (Hexane:EA = 3:1)
3. Client Success Stories
Case Study 1: OLED Material Development
Client: Advanced Optoelectronics Co., Ltd. (Shenzhen, China)
Challenge: Required electron-transport material with LUMO ≤ -3.8 eV
Solution: Synthesized triazine derivatives using 76186-72-6 as core structure
Result: Achieved 18% external quantum efficiency in blue OLED devices
Case Study 2: Anticancer Drug Discovery
Client: Shanghai Medichem Research Institute
Challenge: Needed stable halogenated scaffold for PROTAC development
Solution: Utilized bromine sites for click chemistry functionalization
Result: Produced lead compound with 50 nM IC50 against BTK kinase
4. Technical Inquiry and Custom Solutions
Our technical team specializes in:
- Bulk synthesis (up to 50kg batches)
- Derivative customization (fluoro, iodo, or amino substitutions)
- Analytical support (HPLC, NMR, MS characterization)
Contact our experts:
Email: info@vivalr.com
Phone: (86) 15866781826
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