Carboxymethyl Beta-Cyclodextrin cas 218269-34-2
Assay: ≥98%
Appearance: White or light yellow powder, odourless
Package: 25KG/Drum
Sample: Available
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COA of Carboxymethyl Beta-Cyclodextrin cas 218269-34-2
TDS of Carboxymethyl Beta-Cyclodextrin cas 218269-34-2
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Carboxymethyl Beta-Cyclodextrin (CAS 218269-34-2) Ultimate Guide
Table of Contents
1. Product Specifications & Comparative Analysis
2. Industrial Applications & Functional Advantages
3. Implementation Methodologies
4. Verified Application Scenarios
1. Product Specifications & Comparative Analysis
| Parameter | CM-β-CD | Standard β-CD | HP-β-CD |
|---|---|---|---|
| CAS Number | 218269-34-2 | 7585-39-9 | 128446-35-5 |
| Substitution Degree | 0.6-1.2 | N/A | 0.6-1.0 |
| Water Solubility (25°C) | ≥60g/100ml | 1.85g/100ml | ≥50g/100ml |
| pH Stability Range | 2-12 | 3-8 | 3-10 |
2. Industrial Applications & Functional Advantages
Pharmaceutical Applications:
- Enhance bioavailability of poorly soluble APIs
- Reduce drug toxicity through molecular encapsulation
- Improve chemical stability of oxidation-sensitive compounds
Cosmetic Formulations:
- Controlled release of active ingredients
- Odor masking in topical applications
- Stabilization of volatile components
3. Implementation Methodologies
Complexation Techniques:
- Solution Suspension Method
- Kneading Technology
- Spray-Drying Process
Dosage Optimization:
- Typical host-guest ratio: 1:1 to 4:1
- Optimal temperature range: 25-60°C
- Mixing duration: 2-6 hours
4. Verified Application Scenarios
Case 1: Antifungal Drug Solubility Enhancement
| Parameter | Without CM-β-CD | With CM-β-CD |
|---|---|---|
| Solubility (mg/mL) | 0.12 | 8.75 |
| Dissolution Rate (T80%) | >120min | 15min |
5. Enterprise-Level Utilization Cases
Pharmaceutical Manufacturer A (EU-based):
- Application: Oncology drug formulation
- Challenge: 92% API insolubility
- Solution: 3:1 CM-β-CD complexation
- Result: 12x bioavailability improvement
Cosmeceutical Producer B (US-based):
- Application: Retinol stabilization
- Challenge: 78% degradation in 3 months
- Solution: 2.5% CM-β-CD encapsulation
- Result: <5% degradation after 12 months
6. Professional Consultation & Sample Request
Technical Specifications Sheet Available Upon Request
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