Ethyl Acetoacetate (CAS 141-97-9) Comprehensive Guide
Table of Contents
- Product Overview
- Key Specifications
- Industrial Applications
- Usage Case Studies
- Client Success Stories
- Contact for Quotation
Product Overview
Ethyl acetoacetate (EAA), a colorless liquid with a fruity aroma, serves as a critical intermediate in organic synthesis. Its CAS registry number 141-97-9 identifies this compound composed of molecular formula C6H10O3 and molecular weight 130.14 g/mol. This β-keto ester exhibits keto-enol tautomerism, enabling versatile reactivity.
Key Specifications
| Parameter | Value |
|---|---|
| Boiling Point | 181°C (lit.) |
| Melting Point | -43°C (keto form) |
| Density | 1.021 g/cm³ at 25°C |
| Refractive Index | n20/D 1.419 |
| Flash Point | 84.4°C (closed cup) |
| Solubility | 116 g/L in water (20°C), miscible with organic solvents |
| Vapor Pressure | 1 mmHg at 28.5°C |
Industrial Applications
Pharmaceutical Synthesis
As a building block for antimalarials, antibiotics, and vitamin B1 due to its active methylene group.
Agrochemical Production
Key intermediate in manufacturing herbicides and fungicides through condensation reactions.
Flavor & Fragrance
Source of fruit esters in food additives and perfumery components.
Analytical Chemistry
Metal chelator for spectrophotometric determination of copper and iron ions.
Usage Case Studies
Vitamin B1 Synthesis
In thiamine production, EAA undergoes Claisen condensation with α-picoline to form the pyrimidine moiety.
Antimicrobial Formulations
Pharma companies utilize EAA’s biofilm inhibition properties in topical antiseptic preparations.
Client Success Stories
Shanghai PharmaChem Co., Ltd.
Integrated EAA into their antidiabetic drug intermediates production, achieving 15% yield improvement through optimized acetoacetylation.
Guangzhou Aroma Solutions
Developed a peach-flavored food additive using EAA-derived esters, complying with ISO 22000 standards.
Contact for Quotation
Request technical specifications sheets or bulk pricing:
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