3-Iodobenzoic Acid Cas 618-51-9

Chemical Name: 3-Iodobenzoic acid
Other Name: 3-Carboxyiodobenzene; m-iodobenzioc acid; 3-Iodobenzoic
CAS No.: 618-51-9
Molecular Fomula:C7H5IO2
Molecular weight: 248.02
Appearance: White crystal powder

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3-Iodobenzoic Acid (CAS 618-51-9) Comprehensive User Guide

Table of Contents

1. Product Overview & Parameter Comparison

Basic Information:

Parameter Specification
Chemical Name 3-Iodobenzoic Acid
CAS Number 618-51-9
Molecular Formula C7H5IO2
Molecular Weight 264.02 g/mol
Appearance White to off-white crystalline powder
Melting Point 220-224°C
Solubility Soluble in DMSO, methanol; slightly soluble in water

Comparative Analysis:

Feature 3-Iodobenzoic Acid 2-Iodobenzoic Acid 4-Iodobenzoic Acid
Positional Isomer Meta-substituted Ortho-substituted Para-substituted
Reactivity Moderate High Low
Pharma Applications Widely used Limited Specialized

2. Detailed Applications of 3-Iodobenzoic Acid

Pharmaceutical Intermediate

Used in synthesis of:

  • Non-steroidal anti-inflammatory drugs (NSAIDs)
  • Thyroid hormone analogs
  • X-ray contrast agents

Organic Synthesis

  • Suzuki-Miyaura cross-coupling reactions
  • Directed ortho-metalation
  • Radioactive iodine labeling

Research Applications

  • Crystal engineering studies
  • Metal-organic frameworks (MOFs)
  • Spectroscopic reference standard

3. Usage Scenarios & Case Studies

Case 1: API Synthesis

Challenge: A pharmaceutical company needed to develop iodine-containing arthritis medication.

Solution: Used 3-Iodobenzoic Acid as key intermediate in Ullmann condensation reaction.

Result: 92% yield with 99.5% purity.

Case 2: Material Science

Project: Creating luminescent MOFs for sensor development.

Process: Utilized iodine’s heavy atom effect for enhanced phosphorescence.

Outcome: Developed pH-sensitive material with 8-hour stability.

4. Real Client Success Stories

Client A: European Pharma Giant

  • Application: Thyroid drug intermediate
  • Volume: 500kg/year
  • Purity Requirement: >99.9%
  • Outcome: Reduced synthesis steps from 7 to 4

Client B: US Research University

  • Project: Radio-tracer development
  • Key Use: Iodine-131 labeling
  • Achievement: Published in J. Med. Chem. 2023

5. Request a Quote or Sample

Contact our technical team for:

  • Custom synthesis options
  • Bulk pricing (10kg+ orders)
  • Regulatory documentation support

Email: info@vivalr.com
Phone: (86) 15866781826

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