3-Iodobenzoic Acid (CAS 618-51-9) Comprehensive User Guide
Table of Contents
- 1. Product Overview & Parameter Comparison
- 2. Detailed Applications of 3-Iodobenzoic Acid
- 3. Usage Scenarios & Case Studies
- 4. Real Client Success Stories
- 5. Request a Quote or Sample
1. Product Overview & Parameter Comparison
Basic Information:
| Parameter | Specification |
|---|---|
| Chemical Name | 3-Iodobenzoic Acid |
| CAS Number | 618-51-9 |
| Molecular Formula | C7H5IO2 |
| Molecular Weight | 264.02 g/mol |
| Appearance | White to off-white crystalline powder |
| Melting Point | 220-224°C |
| Solubility | Soluble in DMSO, methanol; slightly soluble in water |
Comparative Analysis:
| Feature | 3-Iodobenzoic Acid | 2-Iodobenzoic Acid | 4-Iodobenzoic Acid |
|---|---|---|---|
| Positional Isomer | Meta-substituted | Ortho-substituted | Para-substituted |
| Reactivity | Moderate | High | Low |
| Pharma Applications | Widely used | Limited | Specialized |
2. Detailed Applications of 3-Iodobenzoic Acid
Pharmaceutical Intermediate
Used in synthesis of:
- Non-steroidal anti-inflammatory drugs (NSAIDs)
- Thyroid hormone analogs
- X-ray contrast agents
Organic Synthesis
- Suzuki-Miyaura cross-coupling reactions
- Directed ortho-metalation
- Radioactive iodine labeling
Research Applications
- Crystal engineering studies
- Metal-organic frameworks (MOFs)
- Spectroscopic reference standard
3. Usage Scenarios & Case Studies
Case 1: API Synthesis
Challenge: A pharmaceutical company needed to develop iodine-containing arthritis medication.
Solution: Used 3-Iodobenzoic Acid as key intermediate in Ullmann condensation reaction.
Result: 92% yield with 99.5% purity.
Case 2: Material Science
Project: Creating luminescent MOFs for sensor development.
Process: Utilized iodine’s heavy atom effect for enhanced phosphorescence.
Outcome: Developed pH-sensitive material with 8-hour stability.
4. Real Client Success Stories
Client A: European Pharma Giant
- Application: Thyroid drug intermediate
- Volume: 500kg/year
- Purity Requirement: >99.9%
- Outcome: Reduced synthesis steps from 7 to 4
Client B: US Research University
- Project: Radio-tracer development
- Key Use: Iodine-131 labeling
- Achievement: Published in J. Med. Chem. 2023
5. Request a Quote or Sample
Contact our technical team for:
- Custom synthesis options
- Bulk pricing (10kg+ orders)
- Regulatory documentation support
Email: info@vivalr.com
Phone: (86) 15866781826



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