6-methylpyridine-3-carboxylic acid cas 3222-47-7

Purity: ≥99%
Appearance: White powder
Packing: 25kg/Fiber Drum
Sample: Available

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6-Methylpyridine-3-Carboxylic Acid (CAS 3222-47-7): Comprehensive Technical Guide

1. Product Overview & Specifications

Parameter Value
Chemical Name 6-Methylpyridine-3-carboxylic acid
CAS Number 3222-47-7
Molecular Formula C7H7NO2
Molecular Weight 137.14 g/mol
Appearance White to off-white crystalline powder
Melting Point 210–213°C
Boiling Point 296.2°C at 760 mmHg
Solubility Sparingly soluble in water
Storage 2–8°C in airtight container

2. Key Applications

This specialty chemical serves critical functions in:

  • Pharmaceutical Synthesis: Key intermediate in production of Etoricoxib (selective COX-2 inhibitor for arthritis treatment)
  • Agrochemical Development: Building block for crop protection agents
  • Material Science: Precursor for functional polymers and coordination complexes
  • Research Chemistry: Chiral ligand in asymmetric catalysis studies

3. Usage Guidelines

Recommended Handling Protocols

  • Use PPE (nitrile gloves, safety goggles) during material handling
  • Conduct reactions under inert atmosphere for oxygen-sensitive processes
  • Optimize reaction temperature between 80–120°C for most coupling reactions

4. Industry Case Studies

Pharmaceutical Intermediate Production

A European API manufacturer achieved 22% yield improvement in Etoricoxib synthesis through optimized purification protocols using 3222-47-7.

5. Client Success Stories

Case 1: Advanced Material Development

Shanghai Pharmaceutical Co. successfully developed a novel metal-organic framework using this compound as a structural template.

Case 2: Process Optimization

Wuhan Fine Chemicals reduced production costs by 18% through improved catalytic systems based on 6-methylnicotinic acid derivatives.

6. Contact for Technical Support

For formulation assistance or bulk purchasing:

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