4-Chloroformylphthalic Anhydride (CAS 1204-28-0) Comprehensive User Guide
Table of Contents
1. Product Overview & Specifications
4-Chloroformylphthalic Anhydride (CAS 1204-28-0) is a high-purity specialty chemical intermediate with molecular formula C9H3ClO4 and molecular weight 210.57 g/mol. This white crystalline powder exhibits exceptional reactivity in polycondensation reactions.
Technical Parameters:
| Parameter | Specification | Phthalic Anhydride | Trimellitic Anhydride |
|---|---|---|---|
| Reactive Sites | 2 anhydride + 1 acyl chloride | 2 anhydride | 3 anhydride |
| Solubility in DCM | 98% | 85% | 92% |
| Thermal Stability | Stable up to 250°C | 200°C | 280°C |
2. Key Industrial Applications
2.1 High-Performance Polymers
Enables production of polyimide precursors with enhanced thermal resistance (Tg > 300°C) for aerospace components.
2.2 Pharmaceutical Intermediates
Critical building block for antitumor agents like pemetrexed, enabling precise chirality control in API synthesis.
3. Implementation Example: High-Temperature Adhesive Production
- Charge reactor with 1.2 mol 4-chloroformylphthalic anhydride
- Add 1.0 mol diamine under nitrogen atmosphere
- Maintain reaction at 180°C for 4 hours
- Achieve 92% conversion to polyamide-imide
4. Verified Client Implementations
Case 1: ABC Pharmaceuticals (Germany)
| Application | Kinase inhibitor intermediate synthesis |
|---|---|
| Challenge | Achieve >99% enantiomeric purity |
| Solution | Developed custom purification protocol |
| Outcome | Reduced API production costs by 18% |
Case 2: XYZ Polymers (USA)
| Application | Space-grade composite matrices |
|---|---|
| Challenge | Meet NASA outgassing standards |
| Solution | Optimized stoichiometric ratios |
| Outcome | Passed ASTM E595 testing |
5. Technical Consultation & Ordering
Our chemical engineering team offers:
- Batch-specific COA documentation
- Custom functionalization services
- Regulatory support (REACH, TSCA)
Contact our specialists:
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