Trimethyl Orthoformate (CAS 149-73-5): Comprehensive User Guide
Table of Contents
1. Product Overview and Specifications
Trimethyl Orthoformate (CAS 149-73-5) is a versatile organometallic compound widely used in organic synthesis. Below are its key parameters:
| Parameter | Trimethyl Orthoformate | Similar Solvents (e.g., Trimethyl Acetate) |
|---|---|---|
| CAS Number | 149-73-5 | N/A |
| Molecular Formula | C4H10O3 | Varies |
| Purity | ≥99% | 90-98% |
| Boiling Point | 102-104°C | Higher volatility |
| Applications | Formylation reactions, protecting groups | Limited versatility |
2. Key Applications and Use Cases
Trimethyl Orthoformate serves critical roles in:
- Pharmaceutical Synthesis: Formyl group introduction in API intermediates.
- Agrochemicals: Precursor for herbicides and insecticides.
- Polymer Chemistry: Crosslinking agent for specialty resins.
3. Practical Implementation Examples
Example 1: Antiviral Drug Intermediate Synthesis
Step 1: React 10 mmol Trimethyl Orthoformate with 8 mmol primary amine under N2.
Step 2: Catalyze with HCl (0.5 eq) at 60°C for 4 hrs.
Yield: 92% formylated product.
4. Customer Success Stories
Case 1: Shanghai PharmaTech Co., Ltd.
Challenge: Low yield (58%) in Remdesivir analog synthesis.
Solution: Optimized formylation using Trimethyl Orthoformate (CAS 149-73-5).
Result: Yield increased to 87% with 99.2% purity.
Case 2: AgriGuard Solutions
Challenge: Unstable intermediates in neonicotinoid production.
Solution: Implemented protective group strategy with Trimethyl Orthoformate.
Result: Production costs reduced by 32%.
5. Request a Quote or Technical Support
Optimize your synthesis processes with premium-grade Trimethyl Orthoformate (CAS 149-73-5):
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