Comprehensive Guide to Tosyl Isocyanate (CAS 4083-64-1)
Table of Contents
- 1. Product Overview & Specifications
- 2. Key Applications & Industry Uses
- 3. Operational Guidelines & Safety Protocols
- 4. Comparative Analysis with Similar Compounds
- 5. Real-World Use Cases
- 6. Client Success Stories
- 7. Contact for Technical Support
1. Product Overview & Specifications
Tosyl Isocyanate (CAS 4083-64-1) is a specialized chemical reagent with the molecular formula C8H7NO3S. Key parameters include:
| Parameter | Value |
|---|---|
| Molecular Weight | 197.21 g/mol |
| Appearance | Colorless to pale yellow liquid |
| Purity | ≥98% |
| Boiling Point | 120-122°C at 10 mmHg |
| Storage Temperature | 2-8°C (under inert atmosphere) |
2. Key Applications & Industry Uses
Primary industrial applications include:
- Pharmaceutical intermediates synthesis
- Polyurethane crosslinking agent
- Surface modification of polymers
- Peptide coupling reactions
- Dye and pigment manufacturing
3. Operational Guidelines & Safety Protocols
Critical handling requirements:
- Use PPE: Nitrile gloves, chemical goggles
- Operate in fume hood with <1 ppm exposure limit
- Incompatible with water, alcohols, amines
- Storage: Argon-purged amber glass containers
4. Comparative Analysis
| Parameter | Tosyl Isocyanate | Phenyl Isocyanate | Methyl Isocyanate |
|---|---|---|---|
| Reactivity | Moderate | High | Extreme |
| Storage Stability | 6-12 months | 3-6 months | Not stable |
| Toxicity | Moderate (LD50 320 mg/kg) | High (LD50 150 mg/kg) | Severe (LD50 51 mg/kg) |
5. Real-World Use Cases
Case 1: Anticancer Drug Intermediate
Used in 5-step synthesis of EGFR inhibitors:
- Initial amine protection
- Controlled isocyanation at 40°C
- Selective deprotection
- Purification via column chromatography
- Final yield: 68% (pharma-grade purity)
Case 2: High-Performance Adhesive
Enhanced polyurethane adhesive formulation:
- 20% increase in bond strength
- Thermal stability up to 180°C
- VOC reduction by 35%
6. Client Success Stories
PharmaSynth Co., Ltd. (2023)
Challenge: Needed scale-up from lab (50g) to pilot (20kg) production.
- Customized purification protocol
- Stabilized batch consistency (98.2-98.7%)
- Reduced production cost by 22%
PolymerTech Solutions (2024)
Application: Conductive polymer modification
- Surface functionalization achieved in 3hr vs 8hr
- Enhanced conductivity: 15 S/cm → 28 S/cm
- Patent filed (US2024178932A1)
7. Technical & Purchasing Support
For SDS, COA, or bulk pricing:
Email: info@vivalr.com
Tel: (86) 15866781826
Request Form:
| Parameter | Options |
|---|---|
| Purity Grade | Industrial (95%), Technical (98%), Pharma (99.5%) |
| Packaging | 1kg glass, 5kg steel, 25kg drum |
| Lead Time | Standard: 2 weeks, Urgent: 5 business days |
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