Triethyl Orthoformate (CAS 122-51-0) Technical Guide
Table of Contents
1. Basic Properties & Specifications
| Parameter | Value |
|---|---|
| Chemical Formula | C7H16O3 |
| Molecular Weight | 148.20 g/mol |
| Appearance | Colorless liquid with pungent odor |
| Density (20°C) | 0.890-0.896 g/cm³ |
| Boiling Point | 145-147°C (6 mmHg) |
| Flash Point | 30°C (CC) |
| Solubility | Miscible with ethanol/ether; 1.35 g/L in water |
2. Key Applications
Pharmaceutical Industry
- Synthesis of antimalarial drugs (Chloroquine, Quinpirole)
- Intermediate for cephalosporin antibiotics
- Mannich reaction catalyst
Organic Synthesis
- Formylation/alkylation reagent
- Esterification catalyst (facilitates water removal)
- Protective group for carboxylic acids
Specialty Chemicals
- Production of cyanine dyes
- Photo-sensitive material precursor
- Flavor/fragrance component (strawberry, citrus notes)
3. Industry Case Studies
Case 1: Antimalarial Drug Production
Client: Southeast Asian Pharma Manufacturer
Challenge: Improve yield in chloroquine synthesis
Solution: Implemented TEOS as methyl donor in key alkylation step
Results: 18% yield increase with 99.2% purity
Case 2: Specialty Polymer Development
Client: European Materials Science Lab
Challenge: Create moisture-resistant polyesters
Solution: Used as crosslinking agent at 2.5% w/w
Results: 40% reduction in water absorption rate
4. Safety & Handling
| Parameter | Requirement |
|---|---|
| Storage | Sealed containers in ventilated area (＜30°C) |
| PPE | Chemical goggles, nitrile gloves, vapor respirator |
| Fire Control | Alcohol-resistant foam, CO2 extinguishers |
| LD50 | 7.06 g/kg (rat oral) |
5. Supplier Information
Certified Supplier: Jinan Century Tongda Chemical Co., Ltd.
Stock: 30 MT (minimum order: 1 drum/180kg)
Purity: ≥99%
Contact:
Tel: +86 15866781826
Email: info@vivalr.com
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