1. Product Overview & Specifications

Tert-Butyldimethylsilyl Chloride (CAS 18162-48-6) is a silicon-based protecting agent widely used in organic synthesis. Key parameters:

2. Key Applications

• Protection of hydroxyl groups in carbohydrate chemistry
• Intermediate in nucleoside analog synthesis
• Steric shielding agent in peptide synthesis
• Selective silylation in complex molecule construction

3. Usage Guidelines

Case Study: Protecting Labile Alcohol Groups

Step 1: Dissolve 1.2 eq TBDMSCl in anhydrous DMF
Step 2: Add 1.0 eq imidazole catalyst
Step 3: React at 0°C for 4 hours
Result: >90% protection yield with minimal side reactions

4. Customer Success Stories

Case 1: PharmaTech Solutions (Shanghai)

Challenge: Degradation of antiviral intermediates during storage
Solution: TBDMSCl protection of critical hydroxyl groups
Outcome: 68% stability improvement at 6-month accelerated testing

Case 2: BioSyntech GmbH (Berlin)

Challenge: Low selectivity in steroid derivatization
Solution: Sequential TBDMSCl/TMSCl protection strategy
Outcome: 92% regioselectivity achieved

5. Request Customized Solutions

Contact our technical team for formulation support:

Email: info@vivalr.com
Phone: (86) 15866781826

Why Choose Us?
– ISO 9001-certified production
– Batch-to-batch consistency guaranteed
– Technical documentation support