1. Product Overview & Specifications

Tauroursodeoxycholic Acid Sodium Salt (CAS 35807-85-3) is a hydrophilic bile acid derivative with the molecular formula C₂₆H₄₄NNaO₆S and molecular weight 521.69. Key properties include:

2. Applications & Mechanisms

Key Functions:

• ER Stress Inhibition: Reduces apoptosis via caspase-3/12 suppression
• Kinase Modulation: Inhibits ERK phosphorylation (IC₅₀: 50 μM in VSMCs)
• Hepatoprotection: Mitigates bile acid-induced cellular damage

Research Areas:

• Oncology (ERK pathway modulation)
• Neurology (Neurodegenerative disease models)
• Metabolic Disorders (Cholestasis therapy)

3. Usage Guidelines

Recommended Protocols:

• In Vitro: 50-200 μM in cell culture medium
• Stability: Store at -20°C (3-year shelf life in dry form)
• Compatibility: Use with Ca²⁺-free buffers for PKCα studies

4. Case Studies

Vascular Smooth Muscle Cell Migration

At 100 μM concentration, achieved 72% inhibition of PDGF-induced VSMC migration through ERK/MKP-1 pathway modulation (Journal of Cardiovascular Pharmacology, 2023).

5. Client Success Stories

PharmaTech Solutions

Integrated TUDCA sodium salt into liver fibrosis drug development, observing 40% reduction in collagen deposition in preclinical models.

NeuroResearch Institute

Used in Alzheimer’s models to demonstrate 35% decrease in neuronal apoptosis via caspase-3 inhibition.

6. Contact for Custom Solutions

Request bulk pricing, COA, or formulation support:

• Email: info@vivalr.com
• Tel: (86) 15866781826