Triisopropylsilyl Chloride (CAS 13154-24-0) Comprehensive User Guide
Table of Contents
- 1. Product Overview & Specifications
- 2. Key Applications & Functional Advantages
- 3. Usage Guidelines & Reaction Examples
- 4. Industry Case Studies
- 5. Technical Support & Quotation Request
1. Product Overview & Specifications
| Parameter | Triisopropylsilyl Chloride | TMSCl | TBDMSCl |
|---|---|---|---|
| CAS Number | 13154-24-0 | 75-77-4 | 18162-48-6 |
| Molecular Formula | C9H21ClSi | C3H9ClSi | C7H17ClSi |
| Molecular Weight | 192.80 g/mol | 108.64 g/mol | 164.76 g/mol |
| Steric Hindrance | High | Low | Medium |
| Typical Reaction Time | 4-8 hrs | 1-2 hrs | 2-4 hrs |
2. Key Applications & Functional Advantages
Core Functions:
- Hydroxyl group protection in nucleosides/carbohydrate chemistry
- Selective silylation in polyfunctional molecules
- Intermediate for silicon-containing materials
Industry Applications:
| Industry | Usage Scenario |
|---|---|
| Pharmaceuticals | Protecting groups in kinase inhibitor synthesis |
| OLED Materials | Precursor for electron-transport layers |
| Agrochemicals | Stabilizing sensitive intermediates |
3. Usage Guidelines & Reaction Examples
Standard Protection Procedure:
ROH + (i-Pr)3SiCl → (i-Pr)3SiOR + HCl
Conditions: DMF, imidazole, 0°C to RT, 90% yield
Stability Data:
| Solvent | Stability (25°C) |
|---|---|
| THF | ＞30 days |
| MeCN | ＞60 days |
4. Industry Case Studies
Case 1: Antiviral Drug Intermediate Production
Client: Top-10 Pharma Company (EU-based)
Challenge: Selective protection of secondary alcohol in ribose derivative
Solution: 0.5M solution in THF with slow imidazole addition
Result: 92% yield, 99.5% purity by HPLC
Case 2: Silicon Nanowire Synthesis
Client: Advanced Materials Startup (USA)
Challenge: Controlled decomposition for Si deposition
Solution: Vapor-phase delivery at 450°C under N2
Result: Uniform 50nm diameter nanowires
5. Technical Support & Quotation Request
Why Choose Us?
- ＞99.8% HPLC purity guaranteed
- Custom packaging (ampoules/drums)
- REACH & TSCA compliant
Contact Our Experts:
Email: info@vivalr.com
Tel: (86) 15866781826
Office Hours: Mon-Fri 08:30-17:30 (GMT+8)
Request Product Sample:
[Submit your application details for free trial quantities]
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