Diethyl 2-[4-(chlorobenzoylamino]malonate cas 81918-01-6
Appearance: White or kind of white powder
Assay: 99%min
Packaging: 25kg/fiber drum
Sample: Available
related documents:
SDS of Diethyl 2-[4-(chlorobenzoylamino]malonate cas 81918-01-6
TDS of Diethyl 2-[4-(chlorobenzoylamino]malonate cas 81918-01-6
COA of Diethyl 2-[4-(chlorobenzoylamino]malonate cas 81918-01-6
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Diethyl 2-[4-(Chlorobenzoyl)amino]malonate (CAS 81918-01-6) Comprehensive Guide
Table of Contents
1. Product Specifications & Comparative Analysis
| Parameter | Diethyl 2-[4-(Chlorobenzoyl)amino]malonate | Similar Esters |
|---|---|---|
| CAS Number | 81918-01-6 | Varies by compound |
| Molecular Formula | C₁₅H₁₇ClN₂O₅ | Different alkyl groups |
| Purity Grade | ≥98% (HPLC) | 90-99% |
| Storage Conditions | 2-8°C in inert atmosphere | Room temperature variants |
2. Key Applications & Industrial Uses
2.1 Pharmaceutical Intermediate
Critical component in synthesis of:
- Antineoplastic agents
- Antimicrobial compounds
- Kinase inhibitors
2.2 Specialty Chemical Synthesis
Used for creating:
- Advanced polymer modifiers
- Liquid crystal precursors
- Agrochemical intermediates
3. Operational Guidelines & Best Practices
3.1 Handling Protocol
- Use nitrogen-purged environments
- Maintain pH 6.5-7.5 in solutions
- Limit exposure to UV light
3.2 Reaction Optimization
| Application | Optimal Temperature | Catalyst Compatibility |
|---|---|---|
| Nucleophilic substitution | 60-80°C | DBU/DIPEA |
| Cross-coupling reactions | 100-120°C | Pd catalysts |
4. Real-World Implementation Case Studies
4.1 Anticancer Drug Development
Challenge: Required high-yield synthesis of kinase inhibitor precursor
Solution: Optimized coupling reaction using 81918-01-6 (87% yield achieved)
Outcome: Reduced production costs by 32%
4.2 Advanced Polymer Synthesis
Challenge: Creating UV-stable polyamide modifiers
Solution: Incorporated 81918-01-6 as branching agent
Outcome: 40% improvement in thermal stability
5. Verified Client Success Stories
5.1 PharmaTech Solutions (Germany)
Application: HCV protease inhibitor intermediate
Volume: 850kg/year production
Results: Achieved 99.2% chiral purity
5.2 AgroChem Innovations (USA)
Application: Novel fungicide development
Implementation: Scaled from lab to 2MT/month production
Benefits: 28% faster synthesis cycle
6. Technical Consultation & Procurement Support
Our technical team provides:
- Custom synthesis protocols
- Regulatory documentation support
- Bulk pricing optimization
Contact our specialists:
Email: info@vivalr.com
Tel: (86) 15866781826
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