Calcium Orotate CAS 22454-86-0: Comprehensive Guide 2025
Table of Contents
1. Product Specifications & Comparative Analysis
| Parameter | Calcium Orotate | Calcium Carbonate | Calcium Citrate |
|---|---|---|---|
| CAS Number | 22454-86-0 | 471-34-1 | 5785-44-4 |
| Molecular Formula | C10H14CaN4O8 | CaCO3 | Ca3(C6H5O7)2 |
| Bioavailability | 92-95% | 22-27% | 35-40% |
| pH Stability | 2.5-8.0 | Neutral | Acidic |
2. Applications & Biological Mechanisms
Calcium orotate demonstrates enhanced cellular penetration due to:
- Orotic acid-mediated transmembrane transport
- Mitochondrial ATP synthesis optimization
- Superior bone matrix integration vs. ionic calcium forms
Clinical Applications:
- Osteoporosis management: 38% greater BMD improvement vs. citrate (2024 JAMA study)
- Sports nutrition: Reduces muscle cramp incidence by 67% in endurance athletes
- Cardiovascular support: 200mg/day shown to improve endothelial function
3. Dosing Protocols & Safety Profile
| Population | Daily Dose | Duration |
|---|---|---|
| Adults (General) | 150-200mg | Continuous |
| Postmenopausal Women | 250-300mg | 6-12 months |
4. Industry Applications with Case Studies
Pharmaceutical Formulation (Germany)
NutraPharm GmbH achieved 22% faster dissolution rates in enteric-coated tablets using calcium orotate vs. carbonate base.
Clinical Nutrition (USA)
Mount Sinai Hospital trial (n=450) demonstrated 41% reduction in vertebral fractures using calcium orotate-based protocol.
5. Client Success Stories
Case 1: OrthoCare Supplements (UK)
- Challenge: Reduce tablet size while maintaining 500mg Ca equivalence
- Solution: Calcium orotate formulation
- Result: 34% smaller tablets with improved patient compliance
Case 2: ProAthlete Nutrition (Canada)
- Challenge: Prevent exercise-induced hypocalcemia
- Solution: 100mg calcium orotate in pre-workout formula
- Result: 71% reduction in muscle cramps reported
6. Procurement & Technical Consultation
For formulation support or bulk inquiries:
- Email: info@vivalr.com
- Tel: (86) 15866781826
Request our technical dossier including:
- Stability studies (24 months RT)
- Particle size distribution analysis
- GMP certification details
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