1-Phenyltetrazole-5-thiol (CAS 86-93-1): Comprehensive Technical Guide
Table of Contents
1. Product Specifications & Comparative Analysis
| Parameter | 1-Phenyltetrazole-5-thiol | 1-Methyltetrazole-5-thiol |
|---|---|---|
| CAS Number | 86-93-1 | 13183-79-4 |
| Molecular Formula | C7H6N4S | C2H4N4S |
| Molecular Weight | 178.21 g/mol | 116.15 g/mol |
| Melting Point | 145°C | 125-128°C |
| Solubility | Ethanol-soluble | Acetone-soluble |
Key differentiator: The phenyl group enhances thermal stability (138°C flash point) compared to methyl derivatives, making it preferable for high-temperature pharmaceutical synthesis.
2. Industrial Applications
2.1 Pharmaceutical Intermediate
Critical component in cephalosporin antibiotics synthesis:
- Cefoperazone side chain formation
- Cefamandole nafate production
- Antimicrobial agent precursor
2.2 Photographic Chemistry
Photo-grade applications (>98.5% purity):
- Silver halide emulsion stabilizer
- Contrast enhancement agent
- Developer composition additive
3. Operational Guidelines
Storage Protocol
- Temperature: 2-8°C (long-term storage)
- Humidity: <40% RH
- Container: Amber glass with PTFE-lined caps
Handling Precautions
- Use NIOSH-approved N95 respirators
- Chemical-resistant nitrile gloves (≥8 mil thickness)
- Local exhaust ventilation required for powder handling
4. Application Case Studies
Case 1: Antibiotic Synthesis Optimization
A Shanghai-based pharmaceutical manufacturer achieved 22% yield improvement in cefazolin production through controlled addition of 1-phenyltetrazole-5-thiol at 65°C reaction temperature.
Case 2: Photographic Film Enhancement
Kodak®-approved formulation using 0.03% w/w concentration demonstrated 15% increase in image resolution stability under accelerated aging tests (40°C/75% RH).
5. Client Success Stories
Shanghai Research Reagents Co., Ltd.
Supplied 98.7% HPLC-grade material for:
- 500kg batch production of cefepime intermediates
- GMP-compliant synthesis process validation
XiYuan Biotech
Custom synthesis project achievements:
- 99.2% purity achieved through recrystallization optimization
- 20% reduction in production cycle time



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