1-phenyltetrazole-5-thiol cas 86-93-1

Chemical Name: 1-Phenyltetrazole-5-thiol
CAS No.: 86-93-1
Molecular Fomula: C7H6N4S
Molecular weight:178.21
Appearance:white crystal
Assay: 99%min

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1-Phenyltetrazole-5-thiol (CAS 86-93-1): Comprehensive Technical Guide

1. Product Specifications & Comparative Analysis

Parameter 1-Phenyltetrazole-5-thiol 1-Methyltetrazole-5-thiol
CAS Number 86-93-1 13183-79-4
Molecular Formula C7H6N4S C2H4N4S
Molecular Weight 178.21 g/mol 116.15 g/mol
Melting Point 145°C 125-128°C
Solubility Ethanol-soluble Acetone-soluble

Key differentiator: The phenyl group enhances thermal stability (138°C flash point) compared to methyl derivatives, making it preferable for high-temperature pharmaceutical synthesis.

2. Industrial Applications

2.1 Pharmaceutical Intermediate

Critical component in cephalosporin antibiotics synthesis:

  • Cefoperazone side chain formation
  • Cefamandole nafate production
  • Antimicrobial agent precursor

2.2 Photographic Chemistry

Photo-grade applications (>98.5% purity):

  • Silver halide emulsion stabilizer
  • Contrast enhancement agent
  • Developer composition additive

3. Operational Guidelines

Storage Protocol

  • Temperature: 2-8°C (long-term storage)
  • Humidity: <40% RH
  • Container: Amber glass with PTFE-lined caps

Handling Precautions

  • Use NIOSH-approved N95 respirators
  • Chemical-resistant nitrile gloves (≥8 mil thickness)
  • Local exhaust ventilation required for powder handling

4. Application Case Studies

Case 1: Antibiotic Synthesis Optimization

A Shanghai-based pharmaceutical manufacturer achieved 22% yield improvement in cefazolin production through controlled addition of 1-phenyltetrazole-5-thiol at 65°C reaction temperature.

Case 2: Photographic Film Enhancement

Kodak®-approved formulation using 0.03% w/w concentration demonstrated 15% increase in image resolution stability under accelerated aging tests (40°C/75% RH).

5. Client Success Stories

Shanghai Research Reagents Co., Ltd.

Supplied 98.7% HPLC-grade material for:

  • 500kg batch production of cefepime intermediates
  • GMP-compliant synthesis process validation

XiYuan Biotech

Custom synthesis project achievements:

  • 99.2% purity achieved through recrystallization optimization
  • 20% reduction in production cycle time

Technical Consultation & Ordering

Email: info@vivalr.com

Tel: (86) 15866781826

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