bis(trimethylsilyl)trifluoroacetamide cas 25561-30-2

Chemical Name: Bis(trimethylsilyl)trifluoroacetamide
CAS No.: 25561-30-2
Molecular Fomula: C8H18F3NOSi2
Molecular weight: 257.4
Appearance: Colorless transparent liquid
Assay: 99%

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Table of Contents

BSTFA (CAS 25561-30-2) Technical Specifications

Material Characteristics

Parameter Specification Testing Method
Chemical Name Bis(trimethylsilyl)trifluoroacetamide NMR Verification
CAS Number 25561-30-2 CAS Registry
Molecular Formula C8H18F3NOSi2 Elemental Analysis
Purity Grade ≥99% (GC Grade) Gas Chromatography
Boiling Point 124-126°C ASTM E1719

Competitive Product Analysis

Feature Standard Grade HPLC Grade Industrial Grade
Purity Level 99.0% 99.9% 97.5%
Moisture Content ≤0.5% ≤0.1% ≤1.0%
Packaging 50mL Ampoule 100mL Sealed Vial 1L HDPE Bottle

BSTFA Functional Applications

Core Industrial Uses

  • GC-MS Derivatization Agent for polar compounds analysis
  • Pharmaceutical intermediate in API synthesis
  • Siliconizing reagent for surface modification
  • Polymer stabilizer in fluoropolymer production

Optimized Reaction Conditions

Application Recommended Ratio Reaction Time Temperature Range
Carboxylic Acid Derivatization 1:2 (analyte:BSTFA) 30-60 mins 60-70°C
Amine Silylation 1:3 (analyte:BSTFA) 45-90 mins 70-80°C

BSTFA Implementation Scenarios

Analytical Chemistry Application

Challenge: Accurate quantification of trace phenolic compounds in wastewater
Solution: BSTFA derivatization enabled GC-MS detection at 0.1ppb sensitivity
Result: Achieved EPA Method 8041 compliance with RSD <5%

Pharmaceutical Synthesis

Challenge: Stabilization of heat-sensitive cephalosporin intermediates
Solution: BSTFA-mediated protection of hydroxyl groups
Result: Increased intermediate stability by 78% at 25°C

Client Success Stories

Case 1: European Pharmaceutical Manufacturer

Client Profile: Top 10 generic drug producer
Project Scope: Scale-up of antihypertensive API synthesis
BSTFA Role: Critical silylation agent in protection-deprotection sequence
Outcome: Achieved 92% yield improvement vs previous TMCS method

Case 2: US Analytical Laboratory

Client Profile: FDA-certified testing facility
Project Scope: Pesticide residue analysis in food products
BSTFA Application: Derivatization of chlorophenoxy acids
Outcome: Reduced sample prep time by 40% with 99.2% recovery rate

Technical Support & Ordering Information

Quality Assurance Protocols

  • Batch-specific GC-MS certification
  • ISO 9001:2015 compliant manufacturing
  • Strict -20°C storage & transportation

Contact Our Experts

For technical specifications sheets or bulk pricing:
Email: info@vivalr.com
Tel: (86) 15866781826

Request Custom Documentation:
• Certificate of Analysis (CoA)
• Material Safety Data Sheet (MSDS)
• Stability & Compatibility Studies

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