Potassium Thioacetate (CAS 10387-40-3): Technical Guide & Applications
Table of Contents
1. Product Overview & Specifications
| Parameter | Value |
|---|---|
| CAS Number | 10387-40-3 |
| Molecular Formula | C2H3KOS |
| Molecular Weight | 114.21 g/mol |
| Appearance | White crystalline powder |
| Melting Point | 173–176°C |
| Density | 1.046 g/cm³ |
| Solubility | Water-soluble |
| Storage | Air-sensitive; store in airtight containers |
2. Key Applications
Pharmaceutical Synthesis
Widely used as a sulfur source in synthesizing antiviral agents (e.g., anti-HIV drugs) and specialty APIs.
Organic Chemistry
Enables thiolation reactions for introducing sulfur atoms into molecular frameworks.
Agrochemical Production
Intermediate in synthesizing sulfur-containing pesticides and herbicides.
3. Usage Guidelines
Handling Precautions
- Use under inert gas (N2 or Ar) to prevent oxidation
- Wear PPE: nitrile gloves, safety goggles, and lab coat
Reaction Conditions
- Optimal temperature range: 20–40°C
- Compatible solvents: THF, DMF, and aqueous systems
4. Industry Case Studies
Case 1: Antiviral Drug Synthesis
A European pharmaceutical company utilized potassium thioacetate as a key intermediate in large-scale production of HIV protease inhibitors, achieving 98.5% reaction yield.
Case 2: Specialty Polymer Production
Japanese materials manufacturer incorporated this compound in thiol-ene click chemistry to develop high-performance adhesives with enhanced thermal stability.
5. Supplier Information
| Supplier | Purity | Packaging |
|---|---|---|
| Wuhan Yusheng Technology | ≥99% | 25 kg/drum |
| Shanghai Chemfish Industrial | ≥98.5% | 1 kg, 5 kg, custom |



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