D-Leucine CAS 328-38-1

Chemical Name: D-Leucine
CAS No.: 328-38-1
Molecular Fomula: C6H13NO2
Molecular weight: 131.17
Appearance: White fine crystals or White power
Assay: 98.0 to 100.5%

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D-Leucine (CAS 328-38-1): Comprehensive Technical Guide

1. Product Overview & Specifications

Parameter D-Leucine L-Leucine
CAS Number 328-38-1 61-90-5
Molecular Formula C6H13NO2 C6H13NO2
Molecular Weight 131.17 g/mol 131.17 g/mol
Optical Rotation -15.45° (C=4, H2O) +15.1° (C=4, H2O)
Melting Point >300°C 293°C
Solubility 24 g/L (25°C in H2O) 22.4 g/L (25°C in H2O)

2. Key Applications

Biomedical Research

Demonstrates superior anti-epileptic activity compared to L-leucine, effectively terminating seizure activity without sedative effects in preclinical models.

Pharmaceutical Development

Used in chiral drug synthesis and as a building block for peptide-based therapeutics targeting neurological disorders.

Biochemical Studies

Critical for protein structure-function analysis and enzyme-substrate interaction studies due to its stereospecific properties.

3. Usage Scenarios

In Vitro Neuroprotection Studies

Applied at 10-100 μM concentrations to modulate neuronal receptor activity while maintaining basal synaptic transmission.

Epilepsy Model Systems

Administered in rodent models at 50 mg/kg doses, showing comparable efficacy to diazepam in seizure suppression.

4. Client Case Studies

Neuropharma Research Institute

Implemented D-Leucine in high-throughput screening of novel antiepileptic agents, achieving 40% faster lead compound identification.

Biotech Peptide Solutions

Utilized in chiral peptide synthesis for blood-brain barrier penetrating therapeutics, improving product purity by 15%.

5. Technical Inquiry

For technical specifications, bulk pricing, or custom synthesis requirements:

Email: info@vivalr.com

Tel: (86) 15866781826

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