chloroacetic anhydride cas 541-88-8

Chemical Name: Chloroacetic anhydride
CAS No.:541-88-8
Molecular Formula: C4H4Cl2O3
Molecular weight: 170.98
Appearance:White crystalline powder
Assay: 96%

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Chloroacetic Anhydride (CAS 541-88-8) Comprehensive Technical Guide

1. Product Overview & Specifications

Parameter Value
CAS Number 541-88-8
Molecular Formula C4H4Cl2O3
Molecular Weight 170.98 g/mol
Appearance Colorless to pale yellow crystalline solid
Melting Point 46°C
Boiling Point 203°C
Density 1.449 g/cm3
Solubility Soluble in chloroform, ether; sparingly soluble in benzene
Flash Point >110°C (closed cup)

2. Key Applications

2.1 Organic Synthesis

  • N-acetylation of amino acids in alkaline solutions
  • Production of chloroacetylated cellulose derivatives
  • Synthesis of specialty polymers and pharmaceutical intermediates

2.2 Industrial Processes

  • Modification of natural polymers for enhanced chemical resistance
  • Cross-linking agent in resin production

3. Operational Guidelines

3.1 Storage Requirements

  • Store in airtight containers at ambient temperature (15-25°C)
  • Maintain relative humidity below 40%
  • Separate from oxidizing agents, acids, and amines

3.2 Handling Procedures

  • Use nitrogen inerting for large-scale operations
  • Employ explosion-proof equipment in processing areas

4. Safety Protocols

Hazard Category GHS Classification Preventive Measures
Acute Toxicity (Oral/Dermal/Inhalation) Category 3 Use NIOSH-approved respirators and butyl rubber gloves
Skin Corrosion Category 1 Wear chemical-resistant suits with sealed seams
Aquatic Toxicity Category 1 Implement secondary containment systems

Emergency Response

  • Eye exposure: Flush with water for 15 minutes using eyewash station
  • Dermal contact: Remove contaminated clothing, wash with pH-neutral soap
  • Spill management: Apply vermiculite absorbent, collect in chemical-resistant containers

5. Industry Use Cases

5.1 Pharmaceutical Manufacturing

Application: Production of antibiotic intermediates through selective acetylation reactions

5.2 Specialty Coatings

Application: Modification of cellulose acetate for high-performance film coatings

6. Technical Consultation & Ordering

For material safety data sheets, custom synthesis inquiries, or bulk pricing:

Email: info@vivalr.com

Tel: (86) 15866781826

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