Chloroacetic Anhydride (CAS 541-88-8) Comprehensive Technical Guide
Table of Contents
1. Product Overview & Specifications
| Parameter | Value |
|---|---|
| CAS Number | 541-88-8 |
| Molecular Formula | C4H4Cl2O3 |
| Molecular Weight | 170.98 g/mol |
| Appearance | Colorless to pale yellow crystalline solid |
| Melting Point | 46°C |
| Boiling Point | 203°C |
| Density | 1.449 g/cm3 |
| Solubility | Soluble in chloroform, ether; sparingly soluble in benzene |
| Flash Point | >110°C (closed cup) |
2. Key Applications
2.1 Organic Synthesis
- N-acetylation of amino acids in alkaline solutions
- Production of chloroacetylated cellulose derivatives
- Synthesis of specialty polymers and pharmaceutical intermediates
2.2 Industrial Processes
- Modification of natural polymers for enhanced chemical resistance
- Cross-linking agent in resin production
3. Operational Guidelines
3.1 Storage Requirements
- Store in airtight containers at ambient temperature (15-25°C)
- Maintain relative humidity below 40%
- Separate from oxidizing agents, acids, and amines
3.2 Handling Procedures
- Use nitrogen inerting for large-scale operations
- Employ explosion-proof equipment in processing areas
4. Safety Protocols
| Hazard Category | GHS Classification | Preventive Measures |
|---|---|---|
| Acute Toxicity (Oral/Dermal/Inhalation) | Category 3 | Use NIOSH-approved respirators and butyl rubber gloves |
| Skin Corrosion | Category 1 | Wear chemical-resistant suits with sealed seams |
| Aquatic Toxicity | Category 1 | Implement secondary containment systems |
Emergency Response
- Eye exposure: Flush with water for 15 minutes using eyewash station
- Dermal contact: Remove contaminated clothing, wash with pH-neutral soap
- Spill management: Apply vermiculite absorbent, collect in chemical-resistant containers
5. Industry Use Cases
5.1 Pharmaceutical Manufacturing
Application: Production of antibiotic intermediates through selective acetylation reactions
5.2 Specialty Coatings
Application: Modification of cellulose acetate for high-performance film coatings
6. Technical Consultation & Ordering
For material safety data sheets, custom synthesis inquiries, or bulk pricing:
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