Propargyl Chloroformate (CAS 35718-08-2): Comprehensive User Guide
Table of Contents
1. Product Overview & Specification Comparison
Basic Properties
| Parameter | Propargyl Chloroformate | Similar Compounds |
|---|---|---|
| CAS Number | 35718-08-2 | N/A |
| Molecular Formula | C4H3ClO2 | Varies by analogue |
| Purity | ≥98% (GC) | Typically 95-99% |
| Storage Temp. | 2-8°C under inert gas | Often RT-stable |
2. Key Applications & Industrial Uses
Core Functional Roles
- Protecting Group Agent: Selective protection of amine groups in peptide synthesis
- Pharmaceutical Intermediate: Critical in NSAID and antiviral drug production
- Crosslinking Facilitator: Enables covalent bonding in polymer networks
3. Operational Guidelines & Best Practices
Reaction Optimization
| Process Phase | Recommended Conditions | Yield Improvement Tips |
|---|---|---|
| Activation | -10°C in anhydrous DCM | Use molecular sieves for moisture control |
| Coupling | 0°C → RT gradual warming | Maintain N2 blanket throughout |
4. Detailed Case Studies
Case 1: Antiviral Drug Synthesis
Challenge: Achieve >90% amine protection in ribavirin precursor
Solution: 1.2eq Propargyl Chloroformate with DMAP catalyst
Outcome: 93% yield with <2% side products
5. Client Success Stories
PharmaSynth Inc. (2023)
Project: Scale-up of kinase inhibitor intermediate
Implementation: 150kg batch production using our GMP-grade material
Results: 40% cycle time reduction vs. traditional methods
PolymerTech Ltd. (2024)
Application: High-temperature adhesive formulation
Technical Support: Custom purity optimization (99.2% achieved)
Impact: 25°C improvement in thermal stability
6. Request Customized Solutions
Contact our chemistry experts for:
– Batch-specific technical data
– Regulatory documentation support
– Custom synthesis projects
Tel: (86) 15866781826
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